Memantine HCl CAS NO.41100-52-1
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017115
CAS NO.41100-52-1
Purity 98%
MDL NumberMFCD00214336
EINEC255-219-6
Molecular FormulaC12H21N.HCl
Molecular Weight215.7628
Melting point: 258°C
| Aspect | Details |
|---|---|
| Chemical Structure | Memantine HCl has the chemical formula C₁₂H₂₁N·HCl. Its chemical name is 1-amino-3,5-dimethyladamantane hydrochloride. |
| Mechanism of Action | Memantine is a low-to-moderate-affinity, voltage- and use-dependent NMDA receptor antagonist. It modulates the activity of glutamate, a neurotransmitter involved in learning and memory, by binding to the NMDA receptor and preventing excessive calcium influx, which is associated with neuronal damage in Alzheimer’s disease. |
| Clinical Uses | It is used for the treatment of moderate to severe Alzheimer’s disease to improve cognitive function and delay disease progression. |
| Formulations | Available as immediate-release tablets/capsules (5 mg, 10 mg) and extended-release capsules (7 mg, 28 mg). The extended-release formulation allows for once-daily dosing. |
| Pharmacokinetics | – Absorption: Well-absorbed orally, with peak plasma concentrations reached in 3–7 hours.<br>- Distribution: Mean volume of distribution is 9–11 L/kg.<br>- Metabolism: Primarily excreted unchanged in urine (48–82%). Metabolized to three main metabolites with minimal NMDA receptor activity.<br>- Elimination: Terminal half-life is approximately 60–80 hours. |
| Special Precautions | – Use with caution in patients with renal impairment. Dose adjustment is required for severe renal impairment (creatinine clearance 5–29 mL/min).<br>- Monitor patients for potential adverse effects such as dizziness, headache, and constipation.<br>- Avoid concurrent use with other central nervous system depressants.<br>- Not recommended for patients with a history of epilepsy or seizure disorders.<br>- Pregnant and breastfeeding women should use with caution. |
| Side Effects | Common side effects include dizziness, headache, constipation, and hypertension. Serious side effects may include hallucinations, confusion, anxiety, and renal dysfunction. |
| Storage Conditions | Store at room temperature (15–30°C) in a dry place |
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