Mefloquine HCl
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80020745
CAS NO.51773-92-3
Purity 95%
MDL NumberMFCD00797519
EINEC257-412-0
Molecular FormulaC17H16F6N2O.HCl
Molecular Weight414.7731
Melting point: 260~265℃
| Category | Information |
|---|---|
| Chemical Properties | Mefloquine HCl is a quinolinemethanol derivative with the chemical name (R*, S*)-(±)-α-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride. It has the molecular formula C₁₇H₁₇ClF₆N₂O with a molecular weight of approximately 416.75. |
| Physical Properties | It appears as a white solid. |
| Mechanism of Action | Mefloquine inhibits hemozoin formation in malaria parasites, leading to an increase in free heme, which is toxic to the parasite. It also acts as an antagonist at the adenosine A2A receptor and an agonist at serotonin 5-HT2A and 5-HT2C receptors. |
| Clinical Uses | – Malaria Prophylaxis and Treatment: Effective against chloroquine-resistant strains of Plasmodium falciparum and P. vivax when used in combination with other antimalarials.<br>- Other Uses: Investigated for use in treating rheumatoid arthritis. |
| Pharmacokinetics | – Absorption: Well-absorbed orally, with peak plasma concentrations reached within 2-3 days.<br>- Distribution: Widely distributed in tissues, with a large volume of distribution.<br>- Metabolism: Metabolized in the liver, with a half-life of approximately 14-25 days.<br>- Excretion: Primarily excreted in feces. |
| Adverse Effects | – Neuropsychiatric: Associated with anxiety, depression, hallucinations, and seizures.<br>- Other: Gastrointestinal disturbances, dizziness, and skin reactions. |
| Contraindications | Contraindicated in patients with active depression, recent history of depression, generalized anxiety disorder, psychosis, schizophrenia, or a history of convulsions. |
| Storage Conditions | Store at +4°C. |
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