Active Pharmaceutical Ingredients

Catalog ID80017116

CAS NO.3685-84-5

Purity 96%

MDL NumberMFCD00012533

EINEC olecular FormulaC12H16ClNO3.HCl

Molecular Weight294.1743

Melting point: 133~135°C

Aspect	Details
Chemical Structure	Meclofenoxate HCl (also known as Centrophenoxine) has the chemical formula C₁₂H₁₆ClNO₃·HCl. It is an ester synthesized from DMAE (dimethylaminoethanol) and pCPA (p-chlorophenoxyacetic acid) .
Mechanism of Action	Meclofenoxate is believed to act primarily through its cholinergic effects. It enhances the production of choline in the brain, which is then converted to acetylcholine, a neurotransmitter crucial for cognitive function. Additionally, it increases cellular membrane phospholipids and has antioxidant properties .
Clinical Uses	It is used as a nootropic agent to improve cognitive function and memory, particularly in elderly individuals with intellectual decline. It is also indicated for the treatment of symptoms of senile dementia, Alzheimer’s disease, and other conditions such as post-stroke encephalopathy, neuritis, and mental disorders .
Formulations	Available as tablets, capsules, and powders for injection. Typical dosing for elderly patients is 3 to 6 tablets (250 mg each) per day, preferably with breakfast and lunch .
Storage Conditions	Store at -20°C .
Side Effects	Common side effects include insomnia (if taken late in the day), gastrointestinal disturbances, and allergic reactions. It may also cause dizziness, headache, and dry mouth .
Special Precautions	Use with caution in patients with a history of gastrointestinal ulcers or other conditions that may be exacerbated by increased gastric acid secretion .
Research Findings	Studies suggest that Meclofenoxate can enhance memory and cognitive functions in the elderly and may reverse some signs of brain aging. It has also shown protective effects on mitochondrial function in vitro .

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