Manidipine 2HCl
We are a manufacturer based in China, specializing in high-quality Manidipine 2HCl for industrial clients worldwide. Technical support and custom formulation available.
Category：Active Pharmaceutical Ingredients | Brand：MT
Factory Direct
7-30 Days Lead Time
MOQ: 100KG
Global Export
Introduction
Catalog ID80019746
CAS NO.89226-75-5
Purity 98%
MDL NumberMFCD00896434
EINEC olecular FormulaC35H38N4O6.2HCl
Molecular Weight683.629
Melting point: 157~163℃
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₃₅H₄₀Cl₂N₄O₆<br>- Molecular Weight: 683.62 |
| Physical Properties | – Appearance: White to off-white solid<br>- Melting Point: Not explicitly mentioned<br>- Solubility: Soluble in DMSO (60 mg/mL), insoluble in water and ethanol |
| Mechanism of Action | – Manidipine 2HCl is a potent calcium channel blocker with an IC₅₀ of 2.6 nM.<br>- It blocks both L-type and T-type calcium channels, resulting in vasodilation and reduced blood pressure. |
| Clinical Uses | – Used for the treatment of hypertension, especially in patients with kidney disease.<br>- Effective in patients with hypertension and type II diabetes or impaired glucose tolerance.<br>- Exhibits renal protective effects superior to amlodipine. |
| Pharmacological Effects | – In Vitro: Inhibits calcium currents in coronary and renal arteries with pIC₅₀ values of 9.3 nM and 9.1 nM, respectively.<br>- In Vivo: Dose-dependently reduces systolic blood pressure in hypertensive rats. |
| Storage Conditions | Store at -20°C for up to 3 years (powder); in solvent at -80°C for up to 1 year. |
| Synonyms | – Manidipine hydrochloride<br>- CV-4093<br>- Calslot |
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