Manidipine 2HCl
We are a manufacturer based in China. We specialize in providing high-quality Manidipine 2HCl for industrial clients across various sectors. Whether you need chemicals consultation or technical support, our team is here to help.
Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80019746
CAS NO.89226-75-5
Purity 98%
MDL NumberMFCD00896434
EINEC olecular FormulaC35H38N4O6.2HCl
Molecular Weight683.629
Melting point: 157~163℃
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₃₅H₄₀Cl₂N₄O₆<br>- Molecular Weight: 683.62 |
| Physical Properties | – Appearance: White to off-white solid<br>- Melting Point: Not explicitly mentioned<br>- Solubility: Soluble in DMSO (60 mg/mL), insoluble in water and ethanol |
| Mechanism of Action | – Manidipine 2HCl is a potent calcium channel blocker with an IC₅₀ of 2.6 nM.<br>- It blocks both L-type and T-type calcium channels, resulting in vasodilation and reduced blood pressure. |
| Clinical Uses | – Used for the treatment of hypertension, especially in patients with kidney disease.<br>- Effective in patients with hypertension and type II diabetes or impaired glucose tolerance.<br>- Exhibits renal protective effects superior to amlodipine. |
| Pharmacological Effects | – In Vitro: Inhibits calcium currents in coronary and renal arteries with pIC₅₀ values of 9.3 nM and 9.1 nM, respectively.<br>- In Vivo: Dose-dependently reduces systolic blood pressure in hypertensive rats. |
| Storage Conditions | Store at -20°C for up to 3 years (powder); in solvent at -80°C for up to 1 year. |
| Synonyms | – Manidipine hydrochloride<br>- CV-4093<br>- Calslot |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.
Inquiry
Factory & Shipment
