Malonyl chloride
Pharmaceutical Materials 2025-03-02
CAS Number: 1663-67-8
Molecular Formula: C3H2Cl2O2
Molecular Weight: 140.95
Appearance: Orange to brown liquid
Melting Point: 53-55°C
Boiling Point: 154.6°C (at 760 mmHg)
Density: 1.5 g/cm3
Usage: Used as an acylating agent in organic synthesis.
| Category | Information |
|---|---|
| Chemical Name | Malonyl chloride |
| Synonyms | Ethanedicarbonyl dichloride; Propanedioyl dichloride |
| CAS Number | 623-43-4 |
| Formula | C3H2Cl2O2 |
| Molecular Weight | 136.95 g/mol |
| Appearance | Colorless to slightly yellow liquid with a pungent odor |
| Density | 1.45 g/mL at 25°C |
| Melting Point | -11.5°C |
| Boiling Point | 147°C |
| Flash Point | 55°C (Closed cup) |
| Refractive Index | 1.437 (at 20°C) |
| Stability | Stable under normal conditions; reacts with water to produce malonic acid and hydrochloric acid; may polymerize under certain conditions |
| Hazard Classification | Corrosive; Flammable liquid; Acute oral toxicity; Skin corrosion/irritation; Serious eye damage/irritation; Respiratory irritation |
| Applications | Used as an intermediate in the synthesis of pesticides, dyes, and pharmaceuticals; also used in the production of malonic acid and its esters |
| Solubility | Soluble in organic solvents such as ether, chloroform, and benzene; insoluble in water |
| Safety Precautions | Keep away from heat, sparks, and open flames; store in a cool, dry, well-ventilated area; wear appropriate protective clothing, gloves, and eye/face protection; avoid contact with skin and eyes; in case of contact, rinse immediately with plenty of water and seek medical advice; follow local regulations for handling, storage, transportation, and disposal. |
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