Active Pharmaceutical Ingredients

Catalog ID80017810

CAS NO.80382-23-6

Purity 98+%

MDL NumberMFCD00941425

Molecular Formula C15H17NaO3

Molecular Weight 268.2835

Melting point: 195~202°C

Aspect	Details
Mechanism of Action	Loxoprofen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a non-selective COX inhibitor, targeting both COX-1 and COX-2 enzymes. It reduces the synthesis of prostaglandins, which mediate inflammation, pain, and fever.
Pharmacokinetics	Loxoprofen sodium is a prodrug that is rapidly absorbed after oral administration and converted into its active metabolite, trans-OH loxoprofen, in the body. It reaches peak plasma concentrations within 1 to 2 hours, with a relatively short half-life of about 1.5 to 2 hours.
Indications	It is used to treat conditions such as rheumatoid arthritis, osteoarthritis, postoperative pain, and other musculoskeletal disorders. It is also used for fever reduction.
Adverse Effects	Common side effects include gastrointestinal disturbances (e.g., nausea, vomiting, dyspepsia), and prolonged use may increase the risk of gastrointestinal ulcers and bleeding.
Storage Conditions	Store in a cool, dry place, protected from light, at a temperature between 10°C and 30°C.
Special Considerations	Use with caution in patients with a history of peptic ulcer disease, renal impairment, or cardiovascular conditions. Regular clinical monitoring (e.g., blood tests, liver function tests) is recommended for long-term use.

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