Loxoprofen sodium CAS NO.80382-23-6
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017810
CAS NO.80382-23-6
Purity 98+%
MDL NumberMFCD00941425
Molecular Formula C15H17NaO3
Molecular Weight 268.2835
Melting point: 195~202°C
| Aspect | Details |
|---|---|
| Mechanism of Action | Loxoprofen sodium is a nonsteroidal anti-inflammatory drug (NSAID) that acts as a non-selective COX inhibitor, targeting both COX-1 and COX-2 enzymes. It reduces the synthesis of prostaglandins, which mediate inflammation, pain, and fever. |
| Pharmacokinetics | Loxoprofen sodium is a prodrug that is rapidly absorbed after oral administration and converted into its active metabolite, trans-OH loxoprofen, in the body. It reaches peak plasma concentrations within 1 to 2 hours, with a relatively short half-life of about 1.5 to 2 hours. |
| Indications | It is used to treat conditions such as rheumatoid arthritis, osteoarthritis, postoperative pain, and other musculoskeletal disorders. It is also used for fever reduction. |
| Adverse Effects | Common side effects include gastrointestinal disturbances (e.g., nausea, vomiting, dyspepsia), and prolonged use may increase the risk of gastrointestinal ulcers and bleeding. |
| Storage Conditions | Store in a cool, dry place, protected from light, at a temperature between 10°C and 30°C. |
| Special Considerations | Use with caution in patients with a history of peptic ulcer disease, renal impairment, or cardiovascular conditions. Regular clinical monitoring (e.g., blood tests, liver function tests) is recommended for long-term use. |
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