Losartan potassium CAS NO.124750-99-8
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80018025
CAS NO.124750-99-8
Purity 98%
MDL NumberMFCD02092704
Molecular Formula C22H22CIKN6OK
Molecular Weight 461.01
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C22H22ClKN6O<br> Molecular weight: 461.01 |
| Physical Properties | Appearance: White to off-white crystalline powder<br> Solubility: Freely soluble in water, soluble in alcohols, slightly soluble in common organic solvents |
| Mechanism of Action | Selective and competitive antagonist of the angiotensin II receptor (AT1 subtype). Blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to reduced blood pressure. |
| Therapeutic Uses | Hypertension: Used as monotherapy or in combination with other antihypertensive agents.<br> Diabetic Nephropathy: Reduces proteinuria and slows progression of kidney disease.<br> Heart Failure: Used in patients intolerant to ACE inhibitors. |
| Pharmacokinetics | Absorption: Well absorbed orally, with a bioavailability of approximately 33%.<br> Distribution: Volume of distribution: 34 L for losartan, 12 L for the active metabolite E-3174.<br> Metabolism: Metabolized in the liver to the active metabolite E-3174, which is 10 to 40 times more potent.<br> Elimination: Half-life of losartan is 2.1 hours, and E-3174 is 7.4 hours. |
| Storage Conditions | Store at room temperature (68–77°F; 20–25°C), protect from light and moisture. |
| Safety Information | Common Side Effects: Dizziness, nasal congestion, back pain.<br> Serious Side Effects: Hypotension, kidney damage, hyperkalemia, allergic reactions.<br> Pregnancy Warning: Discontinue as soon as pregnancy is detected due to fetal toxicity |
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