Lopinavir
Active Pharmaceutical Ingredients 2025-03-03
CAS NO.: 192725-17-0
Molecular formula: C37H48N4O5
Molecular weight: 628.81
Standard: enterprise standard
Content: ≥98.0%
Packaging: 25KG/barrel
Introduction to Lopinavir
| Attribute | Details |
|---|---|
| Chemical Name | (2S)-N-amino]-4-hydroxy-1,6-diphenyl-hexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide |
| Brand Name | Kaletra (in combination with Ritonavir) |
| Mechanism of Action | Lopinavir is a potent inhibitor of HIV-1 protease, preventing the maturation of viral particles and thereby blocking viral replication. It also shows inhibitory activity against SARS-CoV-2 3CLpro, making it a potential antiviral agent for COVID-19. |
| Clinical Uses | – HIV Treatment: Used in combination with ritonavir to treat HIV-1 infection.<br>- COVID-19: Investigated for its potential antiviral activity against SARS-CoV-2.<br>- Hepatitis C: Used in combination with other drugs for treating HCV genotype 4. |
| Pharmacokinetics | – Bioavailability: Poor oral bioavailability when used alone; significantly enhanced when combined with ritonavir.<br>- Metabolism: Metabolized by CYP3A4 in the liver.<br>- Half-Life: Approximately 6–8 hours. |
| Adverse Effects | Common side effects include nausea, vomiting, diarrhea, and headache. Long-term use may lead to metabolic disorders, such as hyperlipidemia. |
| Drug Interactions | – CYP3A4 Inhibitors: May increase plasma levels of lopinavir.<br>- CYP3A4 Inducers: May decrease plasma levels of lopinavir. |
| Formulation | – Combination Therapy: Often combined with ritonavir (100 mg) to enhance its bioavailability and efficacy.<br>- Dosage Forms: Available as tablets and oral solution. |
Lopinavir is a potent HIV-1 protease inhibitor used primarily in combination with ritonavir to treat HIV infection. It has also been explored for its potential antiviral activity against SARS-CoV-2. Its efficacy is significantly enhanced when co-administered with ritonavir, which inhibits the metabolism of lopinavir.
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
