Pharmaceutical Materials

CAS No.60-33-3

Name:

Linolic acid

Synonyms:

linoleoate

emersol 315

emersol 310

Linolic acid

polyin no.515

Linoleic acid

telfairic acid

9.12-linoleicacid

9.12-linoleic acid

9.12-Linoleic acid

(z)-12-octadecadienoicacid

octadeca-9.12-dienoic acid

(Z)-9.12-octadecadienoic acid

12-Octadecadienoicacid(Z,Z)-9

9-cis,12-cis-Octadecadienoate

9.12-Octadecadienoicacid(Z,Z)-

9.12-Octadecadienoic acid (Z,Z)-

cis,cis-9.12-octadecadienoic acid

cis-9.cis-12-octadecadienoic acid

(Z,Z)-Octadeca-9. 12-dienoic acid

9.12-Octadecadieneoic acid, (Z,Z)-

cis,cis-Delta-9.12-octadecadienoate

cis-9.cis-12-Octadecadienoic acid(Z,Z)-9.12-Octadecadienoic acidLinolic acid

CAS    60-33-3

EINECS    200-470-9

InChI    InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7.9-10H,2-5.8.11-17H2.1H3.(H,19.20)

InChIKey    OYHQOLUKZRVURQ-KQHSAVHASA-N

Reference Information：

Introduction:

α-linoleic acid is colorless to pale yellow oily liquid at room temperature, and is easy to oxidize in air. Melting point (°c): -12. boiling point (°c): 230(2.13kPa). Linoleic acid is the body can not be synthesized, or the amount of synthesis can not meet the needs of fatty acids, called essential fatty acids. Linoleic acid and alpha-linolenic acid are clearly defined nutrition essential fatty acids. They are of great significance to human health. But this is not to say that the complement of linoleic acid, increase the intake of linoleic acid, will have a positive effect on human health. On the contrary, when the intake ratio of linoleic acid and alpha-linolenic acid is much higher than 4:1. it will not bring us health, but will make us produce high blood lipids, high blood viscosity and other diseases derived therefrom (such as: Myocardial infarction

Use :

α-linoleic acid is useful as a nutritional supplement, as a drying oil in paints and varnishes, and also in the manufacture of pharmaceuticals.

nutritional supplement, flavoring agent.

hypolipidemic drug for the treatment and prevention of atherosclerosis. Generally no side effects. Long-term use can appear Nausea, Vomit, Diarrhea and other gastrointestinal reactions, continue to administration can gradually disappear.

linoleic acid is an essential fatty acid in human and animal nutrition. Animals and plants have desaturase, can make saturated fatty acid dehydrogenation, produce oleic acid class of unsaturated fatty acids with a double bond, but only plant cells have the ability to further dehydrogenation of oleic acid into linoleic acid. Linoleic acid is a precursor for the synthesis of animal prostaglandins. Lack of linoleic acid, linolenic acid and other fatty acids, will make the animal dysplasia, skin and kidney damage, infertility and so on. Linoleic acid can be combined with cholesterol into Ester, and can promote the degradation of cholesterol into bile acid, and then excreted in vitro, also reduce the role of triglycerides. In medicine for the prevention and treatment of atherosclerosis drugs (such as yishuning, Mai Tong, etc.) raw materials. In industry, linoleic acid used in paint, ink production and preparation of amide, polyester, polyurea. The sodium or potassium salt of linoleate is one of the components of soap and can be used as a surfactant such as an emulsifier. Linoleic acid is non-toxic.

In the human body, metabolites are important nutritional elements of the brain, and have a good role in the prevention and treatment of cardiovascular and cerebrovascular diseases.

Biochemical Study：

range of use：

according to national standards, the recommended dosage is 1‰ to 3.

Overview：

linoleic acid, a fatty acid. The molecular formula CH3(CH2)4CH = CHCH2CH = CH(CH2)7COOH. His name is cis -9.12-octadecadienoic acid. Linoleic acid, together with other fatty acids, is present in animal and vegetable fats and oils in the form of glycerides, and is a main component of drying oils and semi-drying oils such as linseed oil and cottonseed oil, which are formed in the form of glycerides.

toxicity：

GRAS(FDA § 182.5065;§ 184.1065;2000).

usage limit：

GMP(FDA § 182.5065.2000).

 

Attribute	Details
Chemical Name	Linoleic Acid
CAS Number	60-33-3
Synonyms	Linoleate; 9.12-Octadecadienoic Acid; (9Z,12Z)-Octadeca-9.12-dienoic Acid; Linolic Acid; Castor Oil Fatty Acid; etc.
Molecular Formula	C18H32O2
Molecular Weight	280.45 g/mol
Appearance	Yellow or light brown, clear oily liquid with a slight odor of vegetable oil and a spicy taste
Physical Properties	Melting Point: -5°C to -12°C; Boiling Point: 229-230°C at 16 mmHg; Density: 0.902 g/mL at 25°C; Refractive Index: 1.466 at 20°C; Flash Point: >230°F; Insoluble in water, soluble in most organic solvents
Chemical Properties	Sensitive to air and light; Combustible; Incompatible with strong oxidizing agents
Applications	Used as a drying oil in paints and varnishes; also used in the manufacture of drugs; important component of glycerides in oils such as linseed oil, cottonseed oil, and soybean oil
Health Effects	May cause skin irritation; ingestion may cause nausea and vomiting; handle with caution and follow standard chemical safety procedures
Storage Conditions	Store in a cool, ventilated place away from heat, sparks, and open flames; keep container tightly closed and protected from light
Environmental Impact	Can be harmful to the environment; may cause pollution to water bodies and the atmosphere; dispose of according to local regulations

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