Pharmaceutical Materials

LCZ696 Intermediate N-3/Entresto intermediate N-3 Usage： Used as a pharmaceutical intermediate. LCZ696 Intermediate N-3/Entresto intermediate N-3 Packaging and Shipping： 200kg,25kg/drum or as per buyer’s requirements LCZ696 Intermediate N-3/Entresto intermediate N-3 Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid is an organic compound. Its chemical formula is C18H21NO4. Here are some information about its nature, use, formulation and safety:

Nature:

-Appearance: Colorless crystal or white crystalline powder

-Melting Point: about 144-147 ℃

-Solubility: Soluble in some organic solvents, such as methanol, ethanol and dimethyl sulfoxide

Use:

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid is a pharmaceutical intermediate commonly used in the synthesis of drugs. It can be used to synthesize anticancer drugs, antiviral drugs, etc.

Preparation Method:

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid can be prepared by chemical synthesis. The specific preparation method needs to be realized by the technical and chemical steps of organic synthesis, and the specific steps cannot be provided here.

Safety Information:

-When using or handling the compound, follow laboratory safety practices and wear appropriate protective equipment, such as gloves, eye and respiratory protection.

-Avoid inhalation, ingestion or skin contact to avoid dust.

-The compound should be stored in a dry, well-ventilated place, away from fire and oxidizing agents.

-If contact or accidental exposure occurs, immediately flush the affected area with plenty of water and seek help from a doctor.

Name	(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid
Synonyms	LCZ696-24 LCZ696S-01 LCZ696 inter. LCZ-696-001-SS (2R,4S)-5-(4-Biphenylyl)-4-(Boc-amino)-2-methylpentanoic Acid (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (2R, 4S) -5- (biphenyl-4-yl) -4-[(tert-butoxycarbonyl) amino] -2-methylvaleric acid (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid AHU84
CAS	1012341-50-2
EINECS	1592732-453-0

Molecular Formula	C23H29NO4
Molar Mass	383.48
Density	1.115±0.06 g/cm3(Predicted)
Melting Point	145-147°C
Boling Point	582.6±50.0 °C(Predicted)
Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
Appearance	Solid
Color	White to Off-White
pKa	4?+-.0.23(Predicted)
Storage Condition	2-8°C

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