Pharmaceutical Materials

LCZ696 Intermediate II, chemically identified as (R,E)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid, is a critical synthetic intermediate in the production of LCZ696 (Entresto®), a medication used to treat heart failure and hypertension. This compound serves as a precursor in the synthesis of sacubitril, the neprilysin inhibitor component of LCZ696. Its structure features a chiral (R,E)-configured double bond and a tert-butoxycarbonyl (Boc)-protected amine, which are essential for the compound’s reactivity and subsequent transformations. LCZ696 Intermediate II is synthesized through stereoselective reactions and is purified to high purity (≥99%) to ensure its efficacy in pharmaceutical applications. Its role in LCZ696 production underscores its importance in modern cardiovascular drug development.

Usage： Used as a pharmaceutical intermediate.

Packaging and Shipping： 200kg,25kg/drum or as per buyer’s requirements.

Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

Name	(R,E)-5-([1,1′-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid
Synonyms	(R,E)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino) 5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-2-enoic acid 1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid (R,E)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino)-2-methylpent-2-enoic acid (R,E)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid (R,E)-5-([1,1′-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid (2E,4R)-5-[1,1′-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-Pentenoic acid 2-Pentenoic acid, 5-[1,1′-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2E,4R)- (2E,4R)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid AHU83
CAS	1012341-48-8

Molecular Formula	C23H27NO4
Molar Mass	381.46
Density	1.132±0.06 g/cm3(Predicted)
Melting Point	188 – 191°C
Boling Point	595.6±50.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
pKa	4.67±0.19(Predicted)
Storage Condition	Sealed in dry,Room Temperature

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