LCZ696 Intermediate II CAS No.:1012341-48-8
Pharmaceutical Materials 2025-03-02
LCZ696 Intermediate II, chemically identified as (R,E)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid, is a critical synthetic intermediate in the production of LCZ696 (Entresto®), a medication used to treat heart failure and hypertension. This compound serves as a precursor in the synthesis of sacubitril, the neprilysin inhibitor component of LCZ696. Its structure features a chiral (R,E)-configured double bond and a tert-butoxycarbonyl (Boc)-protected amine, which are essential for the compound’s reactivity and subsequent transformations. LCZ696 Intermediate II is synthesized through stereoselective reactions and is purified to high purity (≥99%) to ensure its efficacy in pharmaceutical applications. Its role in LCZ696 production underscores its importance in modern cardiovascular drug development.
Usage： Used as a pharmaceutical intermediate.
Packaging and Shipping： 200kg,25kg/drum or as per buyer’s requirements.
Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.
| Name | (R,E)-5-([1,1′-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid |
| Synonyms | (R,E)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino) 5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-2-enoic acid 1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid (R,E)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino)-2-methylpent-2-enoic acid (R,E)-5-([1,1′-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid (R,E)-5-([1,1′-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid (2E,4R)-5-[1,1′-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-Pentenoic acid 2-Pentenoic acid, 5-[1,1′-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2E,4R)- (2E,4R)-5-[1,1′-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid AHU83 |
| CAS | 1012341-48-8 |
| Molecular Formula | C23H27NO4 |
| Molar Mass | 381.46 |
| Density | 1.132±0.06 g/cm3(Predicted) |
| Melting Point | 188 – 191°C |
| Boling Point | 595.6±50.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 4.67±0.19(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
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