Pharmaceutical Materials

LCZ696 Intermediate 3, chemically identified as (2R,4S)-ethyl 5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride, is a critical chiral intermediate in the synthesis of LCZ696 (Entresto®), a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI) used to treat heart failure and hypertension. This compound features a stereoselective (2R,4S) configuration, essential for the bioactivity of the final drug. It serves as a precursor in the synthesis of sacubitril (AHU-377), the NEP inhibitor component of LCZ696. Its synthesis involves chiral resolution and purification to ensure high enantiomeric purity (≥98%), which is critical for the efficacy and safety of LCZ696. LCZ696 Intermediate 3 plays a pivotal role in modern cardiovascular drug development by enabling the production of this innovative therapy.

Usage： Used as a pharmaceutical intermediate.

Packaging and Shipping： 200kg,25kg/drum or as per buyer’s requirements.

Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

Name	(2R,4S)-ethyl 5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
Synonyms	LCZ698 LCZ696 Intermediate2 (2R,4S)-ethyl 5-([1,1′-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate (2R,4S)-ethyl 5-([1,1′-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate HCl (2R,4S)-ethyl 5-([1,1′-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate hydrochloride (2R,4S)-ethyl 5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
CAS	149690-12-0
EINECS	695-675-7

Molecular Formula	C20H26ClNO2
Molar Mass	347.87894
Melting Point	155 – 162°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Off-White
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

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