Lapatinib ditasylate monohydrate
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80071749
CAS NO.388082-78-8
Purity 98%
Colecular formula C29H26ClFN4O4S.2C7H8O3S.H2O
Molecular weight 943.46
Melting point: >276°C
| Category | Content |
|---|---|
| Generic Name | Lapatinib Ditosylate Monohydrate |
| Chemical Formula | C43H44ClFN4O11S3 |
| CAS Number | 388082-78-8 |
| Mechanism of Action | Lapatinib Ditosylate Monohydrate is a dual inhibitor of EGFR and ErbB-2 tyrosine kinases, with IC50 values of 10.8 nM and 9.2 nM, respectively. It induces cell cycle arrest in the G1 phase and inhibits tumor growth. |
| Indications | – Used for the treatment of advanced breast cancer.<br>- Investigated for other solid tumors. |
| Dosage Forms | Tablets (250 mg, 500 mg) |
| Administration | – Usual dose: 1250 mg orally once daily.<br>- Take with or without food. |
| Common Side Effects | – Diarrhea.<br>- Nausea.<br>- Vomiting.<br>- Fatigue.<br>- Rash. |
| Serious Side Effects | – Liver toxicity.<br>- Cardiotoxicity.<br>- Interstitial lung disease. |
| Precautions | – Monitor liver function regularly.<br>- Use with caution in patients with liver impairment.<br>- Inform your doctor if pregnant or breastfeeding. |
| Storage | Store at -25 to -15°C. |
| Developer | GlaxoSmithKline (GSK) |
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