Pharmaceutical Materials

L-HISTIDINE

CAS No.: 71-00-1
Molecular Formula: C₆H₉N₃O₂
Molecular Weight: 155.16 g/mol

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1. DESCRIPTION

• Appearance: White or almost white crystalline powder/colorless crystals
• Solubility:
  • Freely soluble in water
  • Very slightly soluble in alcohol
  • Insoluble in ether
• Melting Point: 277°C–288°C (with decomposition)

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2. SPECIFICATIONS

Parameter	Standard Value
Appearance of Solution	Clear; ≤ reference solution BY7
Assay	98.5%–101.0%
Specific Optical Rotation	+11.4° to +12.4°
Ninhydrin-Positive Impurities	≤0.5% (any single impurity)
Chloride (Cl)	≤0.02%
Sulfate (SO₄)	≤0.03%
Ammonium (NH₄)	≤0.02%
Iron (Fe)	≤10 ppm
Heavy Metals	≤10 ppm
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

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3. APPLICATIONS

• Nutritional Supplement:
  • Essential component in amino acid infusions and complex preparations.
• Medical Uses:
  • Treatment of gastric ulcers, anemia, and allergic conditions.
  • Supports histamine synthesis and immune function.

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4. PACKAGING & STORAGE

• Packaging: 25 kg/drum (or as per customer requirements).
• Storage: Cool, dry place; protect from light.

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5. NOTES

• Stability: Stable under recommended storage conditions.
• Handling: Avoid prolonged exposure to moisture.

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