Active Pharmaceutical Ingredients

Catalog ID80017753

CAS NO.122892-31-3

Purity 97%

MDL NumberMFCD00881710

Molecular FormulaC20H26N2O4.HCl

Molecular Weight394.8924

Melting point: 191~195℃

Aspect	Details
Mechanism of Action	Itopride HCl is a prokinetic agent that enhances gastrointestinal motility through two primary mechanisms: <br>- Dopamine D2 Receptor Antagonism: Blocks dopamine D2 receptors, preventing dopamine from inhibiting acetylcholine release, thereby promoting gastric motility.<br>- Acetylcholinesterase Inhibition: Inhibits the enzyme acetylcholinesterase, increasing acetylcholine levels in the gastrointestinal tract, which stimulates smooth muscle contractions and enhances peristalsis.
Indications	– Functional dyspepsia.<br>- Gastroesophageal reflux disease (GERD).<br>- Non-ulcer dyspepsia.<br>- Delayed gastric emptying.<br>- Nausea and vomiting.
Dosage	The usual adult dose is 150 mg per day, divided into three doses of 50 mg each, taken before meals.
Contraindications	– Hypersensitivity to itopride or any of its components.<br>- History of gastrointestinal perforation, bleeding, or obstruction.<br>- History of prolactin-secreting pituitary tumors.
Special Precautions	– Use with caution in patients with hepatic or renal impairment.<br>- Monitor for adverse reactions in elderly patients.<br>- Caution in pregnant or breastfeeding women, as safety data are limited.<br>- Avoid long-term use without improvement of symptoms.
Side Effects	– Diarrhea.<br>- Abdominal pain.<br>- Headache.<br>- Dizziness.<br>- Fatigue.<br>- Elevated liver enzymes.
Drug Interactions	– Anticholinergic drugs, which may counteract its prokinetic effects.<br>- Central nervous system depressants, which may enhance sedative effects.<br>- Medications that affect dopamine receptors.
Pharmacokinetics	– Absorption: Rapidly absorbed, with peak plasma concentration reached within 30 to 45 minutes.<br>- Metabolism: Metabolized by flavin-containing monooxygenase in the liver.<br>- Excretion: Primarily excreted via the kidneys.<br>- Half-Life: Approximately 6 hours.

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