Isosorbide
Pharmaceutical Materials 2025-03-02
CAS Number: 652-67-5
Molecular Formula: C6H10O4
Molecular Weight: 146.14 g/mol
Appearance: Light yellow crystalline powder or blocks
Usage: Primarily used as a pharmaceutical intermediate for synthesizing drugs such as isosorbide dinitrate and isosorbide mononitrate, which are used to treat cardiovascular diseases.
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| Category | Details |
|---|---|
| Chemical Name | Isosorbide |
| Synonyms | 1.4:3.6-Dianhydro-D-glucitol; Isosorbide D; Isosorbide, mixture of isomers; D-Isosorbide |
| CAS Number | 652-67-5 |
| Molecular Formula | C6H10O4 |
| Molecular Weight | 146.14 g/mol |
| Appearance | White to off-white solid |
| Density | 1.475 g/cm³ |
| Melting Point | 56-62 °C |
| Solubility | Soluble in water, DMSO, and other organic solvents |
| Uses | Used as an intermediate in the synthesis of various chemicals and pharmaceuticals. It is also used as an oral osmotic diuretic and a vasodilator for the treatment of conditions such as heart failure and angina pectoris. |
| Pharmacological Effects | Has diuretic, vasodilatory, and antiplatelet aggregation activities. |
| Safety Information | Generally recognized as safe for use in appropriate applications. However, avoid inhaling dust, contact with eyes and skin. If swallowed, do not induce vomiting. Rinse mouth and drink 2-4 cupfuls of milk or water if conscious. In case of skin or eye contact, rinse thoroughly with plenty of water and seek medical attention if necessary. |
| Storage Conditions | Store in a cool, dry place, away from direct sunlight and heat. Keep the container tightly closed when not in use. |
