Isoniazide CAS 54-85-3
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Molecular Formula：C6H7N3O
Molecular Weight：137.1
CAS No.:54-85-3
Description
Isoniazid is a white or almost white, crystalline powder or colourless crystals. It is freely soluble in water, sparingly soluble in alcohol.
Application
Isoniazid is the preferred drug for the treatment of tuberculosis, suitable for all types of tuberculosis, such as tuberculosis, lymph, bone, kidney, intestine and other tuberculosis, tuberculous meningitis, pleurisy and peritonitis.
Packing and Storage
Preserve in tight, light-resistant containers. Store at 25°C, excursions permitted between 15°C and 30°C.
Minimum Order
One package
| Item | Content |
|---|---|
| Introduction | Isoniazid (INH) is a first-line antibiotic used to treat tuberculosis (TB) and prevent its progression in high-risk individuals. |
| Mechanism of Action | Isoniazid is a prodrug activated by the bacterial enzyme KatG, generating radicals that inhibit the synthesis of mycolic acids, essential components of the Mycobacterium tuberculosis cell wall. |
| Medical Uses | – Active TB Infection: Used in combination with other drugs.<br>- Latent TB Infection: Used for preventive therapy in high-risk individuals.<br>- Off-label Uses: Treatment of nontuberculous mycobacterial infections. |
| Dosage Forms | – Oral tablets (100 mg, 300 mg)<br>- Oral solution (50 mg/5 mL). |
| Common Side Effects | – Nerve problems (peripheral neuropathy)<br>- Nausea, vomiting, upset stomach. |
| Serious Side Effects | – Liver Damage: Symptoms include jaundice, dark urine, loss of appetite.<br>- Severe Allergic Reactions: Difficulty breathing, swelling of the face or throat. |
| Precautions | – Avoid alcohol to reduce liver damage risk.<br>- Monitor liver function regularly.<br>- Inform your doctor about other medications to avoid interactions. |
| Storage Conditions | Store at room temperature (20°C to 25°C), protect from light and moisture. |
| Contraindications | – Hypersensitivity to isoniazid.<br>- Severe liver disease. |
| Interactions | – Acetaminophen, carbamazepine, ketoconazole, phenytoin, theophylline, valproic acid.<br>- Avoid foods high in tyramine or histamine (e.g., cheese, red wine, certain fish). |
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