Isoconazole nitrate CAS NO.24168-96-5
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017131
CAS NO.24168-96-5
Purity 98%
MDL NumberMFCD01721647
EINEC246-051-4
Molecular FormulaC18H14Cl4N20.HNO3
Molecular Weight479.1414
Melting point: 178~182°C”
| Aspect | Details |
|---|---|
| Chemical Structure | Isoconazole nitrate is an imidazole antifungal agent with the molecular formula C₁₈H₁₅Cl₄N₃O₄ and a molecular weight of 479.14. |
| Mechanism of Action | It acts by altering the permeability of fungal cell membranes, leading to cell death. It also inhibits the biochemical synthesis of fungal cell walls. Additionally, it has broad-spectrum antimicrobial activity against fungi and some gram-positive bacteria. |
| Clinical Uses | Isoconazole nitrate is used topically to treat various fungal infections, including dermatomycoses (skin fungal infections), vaginal mycoses (vaginal yeast infections), and infections caused by Candida species and Malassezia furfur. |
| Formulations | Available as 1% cream for topical application. It can also be combined with corticosteroids (e.g., diflucortolone valerate) to enhance therapeutic benefits, particularly in inflammatory fungal infections. |
| Storage Conditions | Store at 4°C, sealed and away from moisture. |
| Side Effects | Mild to moderate burning or irritation may occur with intravaginal use. |
| Research Findings | In vitro studies show that isoconazole nitrate can rapidly deplete intracellular ATP levels within 10 minutes of exposure and induce cell necrosis at higher concentrations. |
| Regulatory Status | Approved for use since 1982, with regulatory approval in multiple countries. |
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