Pharmaceutical Materials

Product Name

Indomethacin

Multiple Names

Indomethacin Methanol Solution;

Indomethacin Crystalline;

Indomethacin Usp;

Indometacin;

1-(4-Chlorobenzoyl)-5-Methoxy-2-Methylindol-3-Ylacetic Acid;

{1-[(4-Chlorophenyl)Carbonyl]-5-Methoxy-2-Methyl-1H-Indol-3-Yl}Acetate

CAS No. 53-86-1

EC No. 200-186-5

MF No. C19H16ClNO4

MW No. 357.7802

As a pharmaceutical intermediate, it has obvious antipyretic effect.

Advantage of Indomethacin CAS No. 53-86-1

It is widely used in the pharmaceutical intermediate industry.

Product performance is stable.

It is widely used for anti-inflammatory and analgesic in the pharmaceutical industry.

Names and Identifiers

Name	Indomethacin
Synonyms	INDOCIN INDOMETACIN indometacin Indometacin Indomethacin INDOMETACINE AURORA KA-6542 indomethacin usp indomethacin crystalline indomethacin methanol solution 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate
CAS	53-86-1
EINECS	200-186-5
InChI	InChI=1/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)/p-1
InChIKey	CGIGDMFJXJATDK-UHFFFAOYSA-N

53-86-1 – Physico-chemical Properties

Molecular Formula	C19H16ClNO4
Molar Mass	357.79
Density	1.2135 (rough estimate)
Melting Point	158-162 °C
Boling Point	499.4±45.0 °C(Predicted)
Flash Point	255.8°C
Water Solubility	Soluble in acetone (40 mg/mL – clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL – clear, yellow, extremely viscous solution); decomposed by strong alkali
Solubility	Soluble in acetone, slightly soluble in ethanol, chloroform, ether, almost insoluble in water
Vapor Presure	8.61E-11mmHg at 25°C
Appearance	White to bright yellow crystals
Merck	14,4968
BRN	497341
pKa	4.5(at 25℃)
Storage Condition	Store at RT
Stability	Stable. Incompatible with strong oxidizing agents.
Sensitive	Light Sensitive
Refractive Index	1.6800 (estimate)
MDL	MFCD00057095
Physical and Chemical Properties	White or yellowish crystalline powder. Melting point 158-162 ℃. Soluble in acetone, slightly soluble in ethanol, chloroform, ether, almost insoluble in water. Tasteless, almost odorless.
Use	Non-hormonal anti-inflammatory and analgesic drugs

53-86-1 – Risk and Safety

Risk Codes	R28 – Very Toxic if swallowed R36/37/38 – Irritating to eyes, respiratory system and skin. R39/23/24/25 – R23/24/25 – Toxic by inhalation, in contact with skin and if swallowed.
Safety Description	S28 – After contact with skin, wash immediately with plenty of soap-suds. S36/37 – Wear suitable protective clothing and gloves. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 – Wear suitable protective clothing. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN 2811 6.1/PG 1
WGK Germany	3
RTECS	NL3500000
FLUKA BRAND F CODES	8-10
TSCA	Yes
HS Code	29339900
Hazard Class	6.1
Packing Group	I
Toxicity	LD50 i.p. in rats: 13 mg/kg (Klaassen)

53-86-1 – Upstream Downstream Industry

Raw Materials

p-Anisidine 4-Chlorobenzoyl chloride Levulinic acid

 

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