Active Pharmaceutical Ingredients

Catalog ID80017003

CAS NO.53-86-1

Purity 98%

MDL NumberMFCD00057095

EINEC200-186-5

Molecular formula C19H16ClNO4

Molecular weight 357.7876

Aspect	Details
Chemical Structure	– Molecular Formula: C₁₉H₁₆ClNO₄<br>- Molecular Weight: 357.79 g/mol
Mechanism of Action	– Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, reducing the production of prostaglandins that cause pain, inflammation, and fever.
Clinical Uses	– Used to treat moderate to severe pain, inflammation, or arthritis, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gout.<br>- Also used for bursitis, tendonitis, and dysmenorrhea.<br>- Used off-label for conditions like Behçet syndrome and to prevent post-ERCP pancreatitis.
Dosage Forms	– Oral capsules (25 mg, 50 mg)<br>- Extended-release oral capsules (75 mg)<br>- Oral suspension (25 mg/5 mL)<br>- Rectal suppositories (50 mg)<br>- Topical gel.
Storage Conditions	– Oral capsules: Store at room temperature (68°F to 77°F or 20°C to 25°C), protect from light and moisture.<br>- Rectal suppositories: Store in the refrigerator (36°F to 46°F or 2°C to 8°C).<br>- Oral liquid: Store below 86°F (30°C), do not freeze.
Side Effects	– Common: Headache, dizziness, upset stomach, nausea, constipation.<br>- Serious: Gastrointestinal bleeding, ulcers, renal impairment, hypertension, heart failure.<br>- Other: Anemia, increased risk of bleeding, psychiatric disturbances.
Contraindications	– Hypersensitivity to indomethacin or other NSAIDs.<br>- History of gastrointestinal bleeding or ulcers.<br>- Severe heart failure.<br>- Use in late pregnancy (after 30 weeks gestation) due to risk of premature closure of the fetal ductus arteriosus.
Special Precautions	– Use with caution in patients with a history of heart disease, hypertension, liver or kidney disease, asthma, or Parkinson’s disease.<br>- Monitor for signs of gastrointestinal bleeding, especially in elderly patients.<br>- Avoid alcohol and other NSAIDs to reduce the risk of gastrointestinal side effects.
Regulatory Status	– Available by prescription for the treatment of various inflammatory conditions.
Research Applications	– Investigated for its potential in preventing post-ERCP pancreatitis.<br>- Studied for its effects on amyloid beta42 production in Alzheimer’s disease models.

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