Active Pharmaceutical Ingredients

Catalog ID80019668

CAS NO.74431-23-5

Purity 95%

MDL NumberMFCD09753321

Molecular FormulaC12H17N3O4S.H2O

Molecular Weight 317.364

Melting point: 167 – 180°C

Category	Information
Chemical Properties	– Molecular Formula: C₁₂H₁₉N₃O₅S<br>- Molecular Weight: 313.36 g/mol
Physical Properties	– Appearance: White crystalline powder<br>- Melting Point: Not explicitly mentioned
Mechanism of Action	– Imipenem is a carbapenem antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).<br>- It is effective against a broad spectrum of bacteria, including Gram-positive, Gram-negative, and anaerobic organisms.
Clinical Uses	– Used to treat severe infections caused by susceptible bacteria, including pneumonia, sepsis, and infections of the urinary tract, skin, and abdomen.<br>- Often administered in combination with cilastatin to protect imipenem from renal degradation.
Pharmacokinetics	– Absorption: Not effectively absorbed from the gastrointestinal tract; must be administered parenterally.<br>- Distribution: Volume of distribution ranges from 0.23-0.31 L/kg.<br>- Metabolism: Metabolized by renal dehydropeptidase.<br>- Excretion: Approximately 70% excreted in urine.<br>- Half-Life: 1 hour (IV), 1.3-5.1 hours (IM).
Storage Conditions	Store in a cool, dry place, protected from moisture.
Synonyms	– Imipenem monohydrate<br>- Imipenem hydrate<br>- Tienam

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