Imidazole (CAS No. 288-32-4) 

1. Basic Information

• Chemical Name: Imidazole
• Synonyms: 1,3-Diaza-2,4-cyclopentadiene; Glyoxaline
• CAS Number: 288-32-4
• Molecular Formula: C₃H₄N₂
• Molecular Weight: 68.08 g/mol
• Appearance: White to pale yellow crystalline solid
• Odor: Slight ammonia-like odor

2. Physical and Chemical Properties

• Melting Point: 89–91 °C (192–196 °F)
• Boiling Point: 256 °C (493 °F)
• Density: 1.03 g/cm³ (at 20 °C)
• Solubility:
  • Water: Highly soluble
  • Organic solvents: Soluble in ethanol, acetone, chloroform; slightly soluble in ether
• pKa: 6.95 (weak base, amphoteric)
• pH: ~10 (1% aqueous solution)
• Flash Point: 146 °C (closed cup)

3. Chemical Structure

      N  
     / \  
    C   C-H  
   /     \  
  N       C-H

4. Hazards (GHS Classification)

• Health Hazards:
  • Eye/Irritation: Causes severe eye irritation (H319)
  • Skin: May cause irritation (H315)
  • Inhalation: Respiratory irritation possible (H335)
• Environmental Hazards: Harmful to aquatic life (H402)
• NFPA Rating: Health 2, Flammability 1, Reactivity 0

5. Storage and Handling

• Storage: Keep in a cool, dry place away from strong oxidizers.
• Handling: Use PPE (gloves, goggles) in well-ventilated areas.

6. Applications

• Pharmaceutical intermediates (e.g., antifungal agents).
• Biological buffer (e.g., in protein purification).
• Corrosion inhibitor in industrial processes.

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