Ibutilide fumarate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80018881
CAS NO.122647-32-9
Purity 99%
MDL NumberMFCD01715410
Molecular FormulaC24H40N2O7S
Molecular Weight500.6486
Melting point: 116~118°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C44H76N4O10S2<br> Molecular weight: 885.36 |
| Physical Properties | White to off-white solid.<br> Melting point: 117–119°C.<br> Solubility: >100 mg/mL in aqueous solution (pH ≤ 7). |
| Mechanism of Action | Class III antiarrhythmic agent. Prolongs action potential duration and refractory period by activating slow inward sodium currents and blocking rapid delayed rectifier potassium currents (IKr). |
| Pharmacokinetics | High systemic plasma clearance (≈29 mL/min/kg), large volume of distribution (≈11 L/kg), and minimal protein binding (≈40%). Elimination half-life is approximately 6 hours. |
| Therapeutic Uses | Intravenous administration for acute termination of atrial fibrillation and atrial flutter. |
| Safety and Side Effects | Can cause QT interval prolongation and potentially fatal arrhythmias like torsades de pointes. Contraindicated in patients with prolonged QT interval, recent myocardial infarction, or other conditions predisposing to arrhythmias. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture. |
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