Hygromycin hydrochloride
Active Pharmaceutical Ingredients 2025-03-03
Introduction to Hygromycin Hydrochloride
Basic Information
| Attribute | Details |
|---|---|
| Chemical Name | Hygromycin B Hydrochloride |
| Molecular Formula | C₂₀H₃₇N₃O₁₃·HCl |
| Molecular Weight | 563.98 g/mol |
| CAS Number | 1413-61-9 |
| Appearance | White to off-white crystalline powder |
| Solubility | Highly soluble in water and ethanol |
Mechanism of Action and Applications
| Mechanism | Description |
|---|---|
| Target | Binds to the 30S ribosomal subunit of bacteria and eukaryotic cells |
| Effect | Inhibits protein synthesis by interfering with ribosomal translocation |
| Result | Effective against a broad spectrum of microorganisms, including bacteria and fungi |
| Application | Widely used in cell culture for selection of genetically modified cells expressing the hygromycin resistance gene |
Storage and Handling
| Condition | Details |
|---|---|
| Storage Temperature | -20°C (powder form) |
| Storage Medium | Desiccated, protected from light and moisture |
| Shelf Life | 2 years (when stored properly) |
Hygromycin hydrochloride is a potent aminoglycoside antibiotic used primarily in molecular biology for cell selection and maintenance. Its specific mechanism of action and broad-spectrum activity make it a valuable tool in genetic research and cell culture applications.
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