Active Pharmaceutical Ingredients

Introduction to Hygromycin Hydrochloride

Basic Information

Attribute	Details
Chemical Name	Hygromycin B Hydrochloride
Molecular Formula	C₂₀H₃₇N₃O₁₃·HCl
Molecular Weight	563.98 g/mol
CAS Number	1413-61-9
Appearance	White to off-white crystalline powder
Solubility	Highly soluble in water and ethanol

Mechanism of Action and Applications

Mechanism	Description
Target	Binds to the 30S ribosomal subunit of bacteria and eukaryotic cells
Effect	Inhibits protein synthesis by interfering with ribosomal translocation
Result	Effective against a broad spectrum of microorganisms, including bacteria and fungi
Application	Widely used in cell culture for selection of genetically modified cells expressing the hygromycin resistance gene

Storage and Handling

Condition	Details
Storage Temperature	-20°C (powder form)
Storage Medium	Desiccated, protected from light and moisture
Shelf Life	2 years (when stored properly)

Hygromycin hydrochloride is a potent aminoglycoside antibiotic used primarily in molecular biology for cell selection and maintenance. Its specific mechanism of action and broad-spectrum activity make it a valuable tool in genetic research and cell culture applications.

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