Active Pharmaceutical Ingredients

CAS NO: 6153-64-6

6153-64-6 – Names and Identifiers

Name	Oxytetracycline dihydrate
Synonyms	OXYCYCLINE DOXYCYCLINE USP 23 DOXYCYCLINE HYCHLATE OXYTETRACYCLINE HCL BP OXYTETRACYCLINE DIHYDRATE Oxytetracycline dihydrate DOXYCYCLINE HCL ( VETERINARY) DOXYCYCLINE HYDRATE BP98 USP23 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide dihydrate
CAS	6153-64-6
EINECS	612-168-8

6153-64-6 – Physico-chemical Properties

Molecular Formula	C22H28N2O11
Molar Mass	496.46
Melting Point	181-182 °C
Specific Rotation(α)	-216 º (c=1,0.1 M HCl)
Water Solubility	slightly soluble
Solubility	1 M HCl: 0.1M yellow to yellow-orange, clear
Appearance	Yellow crystal
Color	yellow
Storage Condition	Sealed in dry,Room Temperature
MDL	MFCD00151234
Use	This product is for scientific research only and shall not be used for other purposes.
In vitro study	Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.
In vivo study	The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter.For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.

6153-64-6 – Risk and Safety

Risk Codes	R63 – Possible risk of harm to the unborn child R36 – Irritating to the eyes R36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description	S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing.
WGK Germany	3
HS Code	29413000

6153-64-6 – Reference Information

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
biological activity	oxyextracycline Dihydrate is a prescription antibiotic that interferes with the ability of bacteria to produce essential proteins.
Use	prevents aminoacyl-tRNA binding to the 30S subunit, inhibiting protein synthesis (Extended period). antimicrobial spectrum: Gram-negative and Gram-positive bacteria

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