Pharmaceutical Materials

Product Name

Hydroxyethyl Cellulose

Multiple Names

Phosphonic Acid;

Phosphonic Acid;

Hydrogen Phosphonate;

Phosphorus(+3) Trihydride Cation Trihydroxide;

Orthophosphorus;

Orthophosphorous Acid;

Ortho-Phosphorous Acid

CAS No. 9004-62-0

EC No.

MF No. C29H52O21

MW No. 154.25100

Hydroxyethyl cellulose is generally used as thickening agent, protective agent, adhesive, stabilizer, additive for preparing emulsions, jellies, ointments, lotions, eye cleaning agents, suppositories and tablets, as well as hydrophilic gel, skeleton materials, preparation of skeleton type sustained release preparations, and as stabilizer in food.

Advantage of Hydroxyethyl Cellulose CAS No. 9004-62-0

Soluble in cold water and hot water

Odorless, tasteless and easy to flow

With thickening, suspension, adhesion, emulsification, dispersion, moisture retention and other properties

Names and Identifiers

Name	Hetastarch
Synonyms	HEC bl15 ah15 Natrosol cellosize Hetastarch Natrosol LR Natrosol L 250 Natrosol 240JR Natrosol 250 M Natrosol 250 H Natrosol 250 HHR aw15(polysaccharide) aw15[polysaccharide] Hydroxyethyl Cellulose hydroxyl ethyl cellulose 2-hydroxyethylcelluloseether Hydroxyethyl ether cellulose Hydroxyethyl cellulose ether The blood coHydroxyethyl cellulose etherngeals the appearance board 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
CAS	9004-62-0
EINECS	618-387-5

9004-62-0 – Physico-chemical Properties

Molecular Formula	C29H52O21
Density	0.75g/mLat 25°C(lit.)
Melting Point	288-290°C (dec.)
Water Solubility	almost transparency
Solubility	H2O: ≤5wt. % at20°C
Appearance	powder
Color	Light brown powder
Odor	Odorless
Merck	14,4673
PH	pH(20g/l,25℃) : 5.0～8.0
Storage Condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides
Sensitive	Easily absorbing moisture
MDL	MFCD00072770
Physical and Chemical Properties	This product is white to light yellow fibrous or powdery solid, non-toxic, tasteless, soluble in water. Insoluble in general organic solvents. It has the properties of thickening, suspension, adhesion, emulsification, dispersion, and moisture retention. Solutions with different viscosity ranges can be prepared. It has exceptionally good salt solubility to the electrolyte.
Use	Used as surfactant, latex thickener, colloid protective agent, oil fracturing fluid and polystyrene and polyvinyl chloride dispersant

9004-62-0 – Risk and Safety

Hazard Symbols	T – Toxic
Risk Codes	R23/24/25 – Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 – Avoid contact with skin and eyes. S22 – Do not breathe dust.
WGK Germany	3
RTECS	FJ5958000
FLUKA BRAND F CODES	3
HS Code	39123980
Toxicity	LDLo intravenous in women: 5100mg/kg/6D-

 Reference Information

trait	Hydroxyethyl Cellulose is a white or yellowish odorless, tasteless, flowable powder. Both soluble in cold water-soluble hot water, under normal circumstances in most organic solvents insoluble. The viscosity change is small in the pH range of 2-12, but the viscosity decreases beyond this range.
Use	Hydroxyethyl Cellulose is generally used as thickener, protective agent, adhesive, stabilizer and preparation of emulsion, gel, ointment, lotion, eye clearing agent, suppository and tablet additives, also used as hydrophilic gel, matrix material, preparation of matrix type sustained-release preparation, can also be used for food as a stabilizer and so on. This product is used for fracturing oil water-based gel fracturing fluid, polystyrene and polyvinyl chloride polymerization dispersant. Can also be used as paint industry latex thickener, electronic industry Humidity sensitive resistance, construction cement inhibitor and moisture retention agent. Glazing and toothpaste adhesives for the ceramic industry. It is also widely used in printing and dyeing, textile, paper making, medicine, health, food, cigarettes, pesticides and fire extinguishing agents. as a thickener and fluid loss reducer for water-based drilling fluid and completion fluid, the thickening effect is obvious in brine drilling fluid. It can also be used as a fluid loss additive for oil well cement. The gel may be crosslinked with a polyvalent metal ion. It is used as surfactant, colloid protective agent, emulsion stabilizer of vinyl chloride, vinyl acetate and other emulsions, and adhesion promoter, dispersant, dispersion stabilizer and the like of latex. Widely used in coating, fiber, dyeing, papermaking, cosmetics, pharmaceuticals, pesticides and so on. There are also many uses in the oil extraction and machinery industry. used as surfactant, latex thickener, colloid protective agent, petroleum fracturing fluid, polystyrene and polyvinyl chloride dispersant, etc. hydroxyethylcellulose has surface activity, thickening and, suspension, adhesion, emulsification, film formation, dispersion, water retention and protection.
thickener and binder	Hydroxyethyl Cellulose is a commonly used cellulose ether organic water-based ink thickener, belonging to water-soluble non-ionic compounds, it has good thickening ability for water, can be degraded by oxygen, acid and enzyme, and can be crosslinked by Cu2 under alkaline conditions. It is stable to heat, does not appear gelation during heating, does not precipitate under acidic conditions, has good film-forming property, and its aqueous solution can be made into a transparent film, it can be formed by the action of alkaline cellulose and ethylene oxide, and has the properties of thickening, emulsification, adhesion, suspension, film formation, moisture retention and protective colloid. The function of the thickener in the aqueous ink is to thicken. The viscosity of the ink added with the thickener increases, which can improve the physical and chemical stability of the ink. Due to the increase of viscosity, the rheological property of the ink can be controlled during printing, increases the storage stability of aqueous inks. The thickener is a cellulose-based substance and/or a polyvinyl alcohol-based substance. The cellulosic substance may be one or more of methyl cellulose, ethyl cellulose, hydroxymethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, Hydroxyethyl Cellulose and hydroxypropyl methyl cellulose; the polyvinyl alcohol-based material may be one or more of polyethylene 400, 600, 800, 1000, 1600, 2000, 4000, 6000.
range of use	according to national standards, the recommended dosage is 1‰ to 3.
production method	alkali cellulose is a kind of natural polymer, each fiber base ring contains three hydroxyl groups, the most active hydroxyl groups react to produce Hydroxyethyl Cellulose. The raw cotton linter or refined meal pulp was soaked in 30% liquid alkali, and extracted and pressed after half an hour. The crushing was carried out by pressing to 1:2.8 of the alkaline water-containing cases. The crushed alkali cellulose is put into the reaction kettle, closed, vacuumed, filled with nitrogen, and the air inside the kettle is replaced by repeated vacuum and nitrogen filling. The pre-cooled ethylene oxide liquid was pressed into the reaction vessel, and the reaction vessel jacket was introduced into the cooling water to control the reaction at about 25 ℃ for 2H to obtain the crude Hydroxyethyl Cellulose. The crude product was washed with alcohol, neutralized to pH4-6 with acetic acid, and aged with glyoxal. It was then washed with water, centrifuged, dried, and pulverized to give Hydroxyethyl Cellulose. Raw material consumption (kg/t) cotton linter or low meal pulp 730-780 liquid alkali (30%) 2400 ethylene oxide 900 alcohol (95%) 4500 acetic acid 240 glyoxal (40%) 100-300 The raw material cotton linter or refined meal pulp is soaked in 30% alkali solution, taken out after half an hour, and pressed. The mixture was pressed to a ratio of alkaline water of 1: 2.8, and transferred to a pulverizing apparatus for pulverization. The crushed alkali fiber was put into the reaction kettle. Sealed vacuum, nitrogen. After the air in the kettle was replaced with nitrogen gas, the pre-cooled ethylene oxide liquid was forced into the autoclave. The reaction was controlled under cooling at 25 °c for 2 h to obtain crude Hydroxyethyl Cellulose. The crude product was washed with alcohol and adjusted to pH 4-6 by adding acetic acid. Then glyoxal cross-linking aging, washing with water quickly, finally centrifugal drying, grinding, to obtain low salt Hydroxyethyl Cellulose.
spontaneous combustion temperature	725 ° F.

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