Food Additives

CAS No. 9004-65-3

EC No. 618-389-6

MF No. C12H20O10

MW No. 324.2848

Multiple Names Hydroxy Propyl Methyl Cellulose; HPMC; hydroxylpropylmethylcellulose; Hydroxymethylpropylcellulose; isoptoalkaline; isoptoplain; isoptotears; methocele, f, k; HydroxypropylMethylCellulose(Hpmc).

 

Names and Identifiers

Name	Hydroxy Propyl Methyl Cellulose
Synonyms	HPMC hpmcd HPMCP-HP55 isoptoplain isoptotears methocele,f,k isoptoalkaline Hydroxymethylpropylcellulose Hydroxypropyl methylcellulose hydroxylpropylmethylcellulose Hydroxypropyl methyl cellulose Hydroxy Propyl Methyl Cellulose HydroxypropylMethylCellulose(Hpmc) (2R,3R,4S,5R,6S)-3,4,5-trimethoxy-2-(methoxymethyl)-6-[(2R,3R,4S,5R,6R)-4,5,6-trimethoxy-2-(methoxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran 1-[[(2R,3R,4S,5R,6S)-3,4,5-tris(2-hydroxypropoxy)-6-[(2R,3R,4S,5R,6R)-4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran-2-yl]methoxy]propan-2-ol
CAS	9004-65-3
EINECS	618-389-6
InChI	InChI=1/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1

9004-65-3 – Physico-chemical Properties

Molecular Formula	C3H7O*
Molar Mass	59.08708
Density	1.39
Melting Point	225-230 °C
Boling Point	1101.5°C at 760 mmHg
Flash Point	619.9°C
Water Solubility	SOLUBLE
Solubility	H2O: 50mg/mL, clear to very faintly turbid, faintly yellow
Vapor Presure	0mmHg at 25°C
Appearance	White-like powder
Color	White to cream
Odor	Odorless
Merck	14,4842
Storage Condition	room temp
Stability	Stable. Solid is combustible, incompatible with strong oxidizing agents.
MDL	MFCD00131360
Physical and Chemical Properties	Density 1.39 water-SOLUBLE SOLUBLE
Use	Used as a synthetic resin dispersant, coating molding agent, can also be used as a thickening agent

9004-65-3 – Risk and Safety

Safety Description	24/25 – Avoid contact with skin and eyes.
WGK Germany	1
RTECS	NF9125000
FLUKA BRAND F CODES	3-10
TSCA	Yes
HS Code	39129000

Reference Information

Introduction	hydroxypropyl methylcellulose is a propylene glycol ether of methylcellulose, the hydroxypropyl group and the methyl group are both combined with the anhydrous glucose ring of cellulose by ether bond, and are white to off-white cellulose powder or granules, which have the characteristics of cold water dissolution and hot water insolubility similar to methyl cellulose. Solubility in organic solvents is better than water-soluble, soluble in anhydrous methanol and ethanol solution, but also soluble in chlorinated hydrocarbons and ketones and other organic solvents. Soluble in water, its aqueous solution has surface activity, and after drying, it forms a thin film, which undergoes a reversible transition from Sol to gel by heating and cooling. In the cold drink can be used alone, can also be used with other emulsifiers, stabilizers, the largest amount of cold drink 1%. In recent years, it has been widely used in petrochemical industry, paper making, leather, textile printing and dyeing, medicine, food, cosmetics and other industries as dispersants, thickeners, adhesives, excipients, capsules, oil resistant coatings and fillers. FIG. 1 shows the molecular structure of hydroxypropyl methylcellulose.
Usage	Usage: thickener, emulsifier, stabilizer. 1. Note: Hydroxypropyl Methyl Cellulose has a variety of excellent properties, can be used for baking food, paste food, nutritional food, milk stir beverage, pie, filling, salad decorative ingredients and fast food. The use of its thermal gel properties to produce fried food, not only can save a lot of frying oil, and the product has a unique taste of soft inside and outside; The use of its acid, alkali stability, anti-enzyme, not involved in metabolism, enhance the characteristics of gastrointestinal motility, can also be used to manufacture a variety of health food. 2. Use range and usage amount (1) China’s “health standards for the use of food additives” (GB 2760-1996) provides: can be used in all kinds of food according to the production needs. (2) the actual use of reference: the use of this product film and the film of high light transmittance, can be used to manufacture protein casing, the amount of 5%; Used as mayonnaise thickener (HPMC-60RT400), the dosage is 0.5% ~ 2%.
ophthalmic drugs	【medicinal properties and application】 it can promote corneal moisture by stabilizing and thickening the tear film in front of the cornea, it can prolong the cutting time of tear film and prolong the retention time of tear film in dry eyes. Clinical for the lack of tears caused by eye dryness and eye irritation, for the treatment of keratoconjunctivitis sicca, exposure keratitis and neuroparalytic keratitis, to prevent corneal injury; Can be used for hard contact lenses or artificial eye lubricant; it is used for gonioscopy and as a medium to protect the cornea during retinal laser photocoagulation, laser mental plasty or iridectomy when contact lens examination is required. [dosage] eye drops: 0.3% ~ 1% solution, 1 drop, 3~4 times/d. 2% solution of this product was used for Gonioscopy. [attention and contraindication] Sometimes there may be blurred vision or palpebral adhesion. The duration of continuous dripping should not exceed 3d. Wearing soft contact lens is contraindicated in patients with corneal epithelial disease. The lens should be prevented from floating when wearing hard contact lenses. [specification] hydroxypropyl methyl cellulose eye drops: 0.3%,0.5%,1.0%,2.5%. This information was edited by chemical book Xiaonan (2015-08-31).
identification test	solubility may swell in water to form a clear Milky viscous colloidal solution. Insoluble in ethanol. 2, 3 and 4. Are the same as those for “hydroxypropyl cellulose (10012).
toxicity	ADI is not specified (FAO/WHO,2001). Safe for use in food (FDA.§ 172.874,2000). Ld505200 mg/kg (rat, intraperitoneal injection).
usage limit	FAO/WHO(1984): Cold drink 10g/kg (based on the final product, used alone or in combination with other emulsifiers, stabilizers and thickeners). GB 2760-96: all kinds of food, GMP is the limit.
Use	thickening agent; Stabilizer; Emulsifier; Gelling agent; Suspending agent. used as a synthetic resin dispersant, coating molding agent, can also be used as a thickener This product is used in the textile industry as a thickener, dispersant, binder, emulsifier and stabilizer. Also widely used in synthetic resin, petrochemical, ceramics, paper, leather, medicine, food, cosmetics and other industries. used in synthetic resin, petrochemical industry, ceramics, paper making, leather, textile printing and dyeing, medicine, food, cosmetics and other daily chemicals, as dispersant, thickener, binder, excipient, capsule, oil-resistant coatings and fillers, etc.
production method	The refined cotton cellulose was treated with alkali solution at 35-40 ° C. For half an hour, and the cellulose was crushed by pressing, the aging is suitably carried out at 35 ° C. So that the obtained average degree of polymerization of the alkali fiber is in the desired range. The alkali fiber is put into the etherification kettle, propylene oxide and methyl chloride are sequentially added, and the etherification is carried out at 50-80 ° C. For 5h, and the maximum pressure is about 1.8MPa. The reaction product was worked up (neutralization with hydrochloric acid, iron removal with oxalic acid, washing, drying). Raw material consumption quota cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, Solid alkali 1200kg/t, hydrochloric acid 30kg/t, oxalic acid 50kg/t. 100 of the refined short cotton wool was immersed in a 45% alkali solution at a temperature of 35 to 40 ° C. For 0.5 to 1.0 h, and then taken out and pressed. Pressure was stopped when the weight was 2.7 times the weight of cotton wool. Crushing and loosening were performed. Aging at 35 C for 16 h. Put the aged alkali fiber into the reaction kettle, add methyl chloride and propylene oxide in turn, and react for 5~8 h at 80 ℃ and 1.8 MPa, then, hydrochloric acid and oxalic acid were added to hot water at 90 ° C. To wash the material to enlarge the volume. Dehydrate with a centrifuge. Washing was carried out to neutrality and when the water content in the material was less than 60%, drying was carried out in a stream of hot air at 130 °c until the water content was less than 5%. The final product was crushed through a 20-mesh screen. prepared from cellulose, methyl chloride and ethylene oxide.

Basic Information

Attribute	Details
Name	Hydroxy Propyl Methyl Cellulose (HPMC)
CAS Number	9004-65-3
Formula	(C6H12O6)x(C3H7O2)y(CH3)z
Appearance	White to off-white, odorless powder

Properties and Characteristics

Attribute	Details
Solubility	Soluble in cold water, forming a clear, viscous solution
Viscosity	Ranges from low to high, depending on product grade
Stability	Stable in a wide range of pH conditions, resistant to heat and enzymes
Film-forming	Forms a tough, clear film upon drying

Applications

Attribute	Details
Industry	Used as a thickener, stabilizer, and emulsifier in various industries
Pharmaceuticals	As a binder, coating agent, and disintegrant in tablets
Food	As a texture modifier and stabilizer in processed foods
Cosmetics	As an emulsifier and stabilizer in personal care products

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