hydroxy-4,5-dimethoxybenzoic acid CAS 5722-93-0
Pharmaceutical Materials 2025-03-03
2-Hydroxy-4,5-dimethoxybenzoic acid (2-H4,5DMBA) is a white to off-white crystalline compound with the molecular formula C₉H₁₀O₅ and a molecular weight of 198.17 g/mol. It is primarily recognized as a key intermediate in the synthesis of acotiamide, a prokinetic agent used for functional dyspepsia. Beyond pharmaceuticals, 2-H4,5DMBA serves as a building block for antioxidants, corrosion inhibitors, and specialty chemicals. Its synthesis typically involves methylation of 2,4,5-trihydroxybenzoic acid followed by hydrolysis of the corresponding methyl ester. The compound exhibits moderate thermal stability, decomposing above 213°C, and is sparingly soluble in water but soluble in organic solvents like ethanol and ethyl acetate. Due to its role in pharmaceutical pipelines and chemical synthesis, 2-H4,5DMBA is a valuable reagent in both research and industrial applications.
Usage： It is used Pharmaceutical intermediates; Intermediate of atecoline hydrochloride.
Packaging and Shipping： 25kgs/Bag or Drum or as required by buyer.
Storage: Store in a cool, ventilated place, protect from sun, heat and moisture.Storage and transportation according to general chemical regulations.
| Name | 2-Hydroxy-4,5-Dimethoxy Benzoic Acid |
| Synonyms | Acotiamide Impurity K Acotinamide Impurity 4 4,5-DiMethoxysalicylic acid 2-hydroxy-4,5-dimethoxybenzoic 2-Hydroxy-4,5-dimethoxybenzoic acid Acotiamide Hydrochloride impurity J 2-Hydroxy-4,5-Dimethoxy Benzoic Acid 2-HYDROXY-4,5-DIMETHOXY BENZOIC ACID 2-Hydroxy-4,5-Dimethoxy Benzoic Acid (for Acotiamide) |
| CAS | 5722-93-0 |
| EINECS | 1312995-182-4 |
| Molecular Formula | C9H10O5 |
| Molar Mass | 198.17 |
| Density | 1.335±0.06 g/cm3(Predicted) |
| Melting Point | 213-214℃ (decomposition) |
| Boling Point | 361.5±42.0 °C(Predicted) |
| Appearance | White or white-like solid |
| pKa | 3.13±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
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