Higenamine HCl
We are a manufacturer based in China. We specialize in providing high-quality Higenamine HCl for industrial clients across various sectors. Whether you need chemicals consultation or technical support, our team is here to help.
Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride
Catalog ID100045
CAS NO.11041-94-4
Purity 98%
MDL NumberMFCD01717353
EINEC Molecular FormulaC16H17NO3.HCl
Molecular Weight307.775
Appearance:Off-white solid
| Category | Content |
|---|---|
| Generic Name | Higenamine Hydrochloride |
| Chemical Formula | C16H18ClNO3 |
| CAS Number | 11041-94-4 |
| Mechanism of Action | Higenamine hydrochloride is a selective β2-adrenergic receptor (β2-AR) agonist. It also acts as an α1-adrenergic receptor antagonist and a selective LSD1 inhibitor (IC50 = 1.47 μM) . |
| Pharmacological Properties | – Anti-inflammatory and Antioxidant Activity: Protects myocardial cells from apoptosis and ischemia/reperfusion injury .<br>- Cardioprotective Effects: Reduces myocardial infarction in mice .<br>- Neuroprotective Effects: Protects brain cells from oxygen deprivation and reduces ischemic injury in rats .<br>- Bone Formation: Promotes osteogenesis in osteoporosis models . |
| Clinical Trials and Studies | – Ischemia/Reperfusion Injury: Higenamine hydrochloride (10 mg/kg) reduces myocardial infarct areas in mice .<br>- Cardiorenal Syndrome: Improves cardiac and renal function in rats with CRS .<br>- Osteoporosis: Promotes bone formation in SAMP6 mice models . |
| Physical Properties | – Appearance: Pale beige to pale brown solid .<br>- Solubility: Slightly soluble in DMSO and methanol; insoluble in water .<br>- Storage: Store at 4°C, protect from light . |
| Toxicity | Mouse LD50 (intravenous): 17.25 mg/kg . |
| Applications | – Research: Used in studies related to heart failure, inflammation, cancer, and cardiorenal syndrome .<br>- Medicinal Uses: Potential therapeutic applications in cardiovascular and neurological disorders . |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.
Inquiry
Factory & Shipment
