Higenamine HCl
Active Pharmaceutical Ingredients 2025-03-03
English Synonyms 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride
Catalog ID100045
CAS NO.11041-94-4
Purity 98%
MDL NumberMFCD01717353
EINEC Molecular FormulaC16H17NO3.HCl
Molecular Weight307.775
Appearance:Off-white solid
| Category | Content |
|---|---|
| Generic Name | Higenamine Hydrochloride |
| Chemical Formula | C16H18ClNO3 |
| CAS Number | 11041-94-4 |
| Mechanism of Action | Higenamine hydrochloride is a selective β2-adrenergic receptor (β2-AR) agonist. It also acts as an α1-adrenergic receptor antagonist and a selective LSD1 inhibitor (IC50 = 1.47 μM) . |
| Pharmacological Properties | – Anti-inflammatory and Antioxidant Activity: Protects myocardial cells from apoptosis and ischemia/reperfusion injury .<br>- Cardioprotective Effects: Reduces myocardial infarction in mice .<br>- Neuroprotective Effects: Protects brain cells from oxygen deprivation and reduces ischemic injury in rats .<br>- Bone Formation: Promotes osteogenesis in osteoporosis models . |
| Clinical Trials and Studies | – Ischemia/Reperfusion Injury: Higenamine hydrochloride (10 mg/kg) reduces myocardial infarct areas in mice .<br>- Cardiorenal Syndrome: Improves cardiac and renal function in rats with CRS .<br>- Osteoporosis: Promotes bone formation in SAMP6 mice models . |
| Physical Properties | – Appearance: Pale beige to pale brown solid .<br>- Solubility: Slightly soluble in DMSO and methanol; insoluble in water .<br>- Storage: Store at 4°C, protect from light . |
| Toxicity | Mouse LD50 (intravenous): 17.25 mg/kg . |
| Applications | – Research: Used in studies related to heart failure, inflammation, cancer, and cardiorenal syndrome .<br>- Medicinal Uses: Potential therapeutic applications in cardiovascular and neurological disorders . |
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