Active Pharmaceutical Ingredients

Griseofulvin is a non-polyene antifungal antibiotic. It can strongly inhibit fungal cell mitosis, interfere with fungal DNA synthesis, and it binds to tubulin to prevent fungal cell division. Griseofulvin is not only an antibiotic commonly used in the clinical treatment of skin and stratum corneum fungal infections, but also in agriculture, it is also used for the prevention and treatment of fungal diseases. A candidiasis in apples can cause infections during flower pollination. , And it has a special effect on this.

Molecular Formula：C17H17ClO6

Molecular Weight：352.77

CAS No.: 126-07-8

Description:Griseofulvin is a white or yellowish-white, microfine powder, the particles of which generally have a maximum dimension of up to 5 µm, although larger particles that may exceed 30 µm may occasionally be present. It is practically insoluble in water, freely soluble in dimethylformamide and in tetrachloroethane, slightly soluble in anhydrous ethanol and in methanol.

Application:In medicine, Griseofulvin is suitable for the treatment of various tinea diseases, including tinea capitis, tinea whiskers, tinea corporis, tinea cruris, tinea pedis and tinea nail.

In agriculture, Griseofulvin can control plant diseases.

Packing and Storage:Preserve in tight container.

Minimum Order

One package

Griseofulvin: A Veterinary Antifungal Agent

Griseofulvin is an important antifungal agent in veterinary medicine, used to treat various fungal infections in animals.

1. General Characteristics

Aspect	Details
Classification	Antifungal antibiotic
Source	Produced by Penicillium griseofulvum. It can also be synthesized semi – synthetically.
Formulation	Available as tablets, capsules, and oral suspensions for oral administration to animals. In some cases, it may be formulated into topical creams or ointments for external use, although systemic treatment is more common.
Solubility	Sparingly soluble in water. Special formulations or administration methods are often required to ensure proper absorption and bioavailability in animals.

2. Mechanism of Action

Action	Explanation
Inhibition of Fungal Cell Division	Griseofulvin binds to microtubules in fungal cells. Microtubules play a crucial role in cell division, specifically in spindle formation. By binding to these microtubules, griseofulvin disrupts the normal assembly and function of the spindle apparatus. As a result, fungal cell division is inhibited, leading to the arrest of fungal growth.
Selective Activity	It has a specific antifungal activity, mainly targeting dermatophytes, which are the fungi that cause skin, hair, and nail infections in animals. These include species like Microsporum canis and Trichophyton mentagrophytes. It works by interfering with the mitotic process unique to these fungal organisms.

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating ringworm infections in cats, dogs, and other animals. Ringworm, caused by dermatophytes, is a common fungal skin infection. Griseofulvin is effective in clearing up the infection and promoting healing of the affected skin areas. – Used to manage fungal infections of the hair and nails in animals. In cases where the fungal infection has spread to the hair follicles or nails, griseofulvin can be used to eliminate the pathogen.
Considerations	– Long – term use may be required for complete eradication of fungal infections, especially in stubborn cases. This can increase the risk of side effects. – Side effects may include gastrointestinal upset in animals, such as vomiting, diarrhea, and loss of appetite. It may also cause liver enzyme elevation in some cases, so monitoring of liver function may be necessary during treatment. – Caution is needed when using it in pregnant animals, as it may have teratogenic effects. Consultation with a veterinarian is essential before using it in such cases.

Griseofulvin plays a significant role in maintaining the dermatological health of animals by effectively treating fungal infections.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.