Glycine methyl ester hydrochloride
Pharmaceutical Materials 2025-03-02
CAS Number: 5680-79-5
Molecular Formula: C3H8NClO2 or C3H7NO2·HCl
Molecular Weight: 125.55 g/mol Appearance: White crystalline powder
Usage: Used as an intermediate for pesticides, pyrethroids, and pharmaceutical industries.
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| Category | Details |
|---|---|
| Chemical Name | Glycine methyl ester hydrochloride |
| Synonyms | Glycine methylester hcl; Methyl glycinate hydrochloride; H-Gly-OMe·HCl; Aminoacetic acid methyl ester hydrochloride; L-Glycine methyl ester hydrochloride |
| CAS Number | 5680-79-5 |
| EINECS Number | 227-139-1 |
| Molecular Formula | C3H8NClO2 |
| Molecular Weight | 125.55 g/mol |
| Appearance | White crystalline powder at room temperature |
| Melting Point | 173°C (lit.) |
| Solubility | Highly soluble in water (>1000 g/L at 20°C); slightly soluble in ethanol; hygroscopic |
| Chemical Structure | NH2CH2COOCH3·HCl |
| Chemical Properties | Stable under normal conditions but hygroscopic, meaning it easily absorbs moisture from the air. |
| Common Chemical Reactions | Involves reactions related to its amino group salification and ester group. |
| Applications | – Used as an intermediate in the production of pesticides, such as pyrethroids, and pharmaceuticals. – Important intermediate for the synthesis of (chrysanthemum acid) and dichlorochrysanthemum acid. – Intermediate in the production of fungicides, such as iprodione. – Used in organic synthesis. |
| Preparation Methods | Prepared from glycine or chloroacetic acid: – Glycine-based method: Involves reacting glycine with methanol in the presence of hydrogen chloride. – Chloroacetic acid-based method: Reacting chloroacetic acid, hexamethylenetetramine, and methanol with ammonia, followed by acidification. |
| Safety Information | Considered low in toxicity with limited toxicity data available. Its toxicity can be referenced to glycine. Avoid contact with skin and eyes due to the presence of hydrochloric acid. Store in a cool, dry, well-ventilated area, away from strong acids, bases, and oxidizing agents. |
