Pharmaceutical Materials

CAS Number: 122-60-1

Molecular Formula: C9H10O2

Molecular Weight: 150.17 g/mol

Appearance: Colorless to pale yellow liquid

Melting Point: 3.5°C

Boiling Point: 242.5°C

Density: 1.1109 g/mL at 21.2/4°C

Usage: Used as an intermediate in organic synthesis, particularly in the production of epoxy resins.

Attribute	Details
Chemical Name	Glycidyl phenyl ether
CAS Number	122-60-1
Synonyms	Phenyl glycidyl ether, 1.2-Epoxy-3-phenoxypropane, (2.3-epoxypropoxy)-benzene
Molecular Formula	C9H10O2
Molecular Weight	150.174 g/mol
Physical State	Colorless liquid
Density	1.1±0.1 g/cm³
Melting Point	3.5 °C
Boiling Point	245.0±0.0 °C at 760 mmHg
Flash Point	94.8±19.4 °C or 110 °C (varying data)
Refractive Index	1.5307 at 21 °C
Solubility	Soluble in ether and benzene, insoluble in water
Vapor Density	5.2 (vs air)
Vapor Pressure	0.03 mm Hg at 20 °C or 0.0±0.4 mmHg at 25 ℃ (varying data)
Main Uses	Intermediate in organic synthesis and pharmaceutical chemistry
Preparation Method	Prepared through nucleophilic substitution reaction between phenol and chlorinated epoxy compounds
Safety Information	Irritant to skin, eyes, and respiratory system. Store in a cool, dry place, away from oxidants. Wear appropriate protective gear.

 Names and Identifiers

Name	Phenyl Glycidyl Ether
Synonyms	PGE PHENYL GLYCID ETHER PHENYL GLYCIDYL ETHER Phenyl tlycidyl ether Glycidyl Phenyl Ether Phenyl Glycidyl Ether GLYCIDYL PHENYL ETHER 3-phenoxy-1,2-epoxypropane 2,3-EPOXYPROPYL PHENYL ETHER PHENYL 2,3-EPOXYPROPYL ETHER 1-PHENOXY-2,3-PROPYLENE OXIDE
CAS	122-60-1
EINECS	204-557-2
InChI	InChI=1/C6H10O3.C6H6O/c1(5-3-8-5)7-2-6-4-9-6;7-6-4-2-1-3-5-6/h5-6H,1-4H2;1-5,7H
InChIKey	FQYUMYWMJTYZTK-UHFFFAOYSA-N

122-60-1 – Physico-chemical Properties

Molecular Formula	C9H10O2
Molar Mass	150.17
Density	1.109g/mLat 25°C(lit.)
Melting Point	3.5°C(lit.)
Boling Point	245-247°C(lit.)
Flash Point	>230°F
Water Solubility	2.4 g/L (20 ºC)
Solubility	2.4g/l
Vapor Presure	0.03 mm Hg ( 20 °C)
Vapor Density	5.2 (vs air)
Appearance	Liquid
Color	Clear colorless to yellow
Exposure Limit	TLV-TWA 6 mg/m3(1 ppm) (ACGIH);1 ppm (15 min) (NIOSH).
BRN	2744
Storage Condition	Store below +30°C.
Stability	Stable. Incompatible with strong oxidizing agents.
Refractive Index	n20/D 1.531
Physical and Chemical Properties	Colorless transparent liquid. Melting point 3.5 ℃, boiling point 242.5 ℃(100kPa), relative density 1.1109(21.2/4 ℃), refractive index 1.5307(21 ℃). Soluble in ether, benzene, insoluble in water, with water vapor volatilization.

122-60-1 – Risk and Safety

Hazard Symbols	T – Toxic
Risk Codes	R45 – May cause cancer R20 – Harmful by inhalation R37/38 – Irritating to respiratory system and skin. R43 – May cause sensitization by skin contact R52/53 – Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R68 – Possible risk of irreversible effects
Safety Description	S53 – Avoid exposure – obtain special instructions before use. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 – Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	2810
WGK Germany	3
RTECS	TZ3675000
TSCA	Yes
HS Code	29109000
Hazard Class	IRRITANT
Toxicity	LD50 orally in Rabbit: 2150 mg/kg LD50 dermal Rabbit 1500 mg/kg

122-60-1 – Reference Information

LogP	1.61 at 25℃
(IARC) carcinogen classification	2B (Vol. 47, 71) 1999
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Use	is useful as an intermediate in organic synthesis.
production method	is obtained by condensation of phenol and epichlorohydrin in the presence of sodium hydroxide. Phenol and sodium hydroxide were mixed and stirred until all were dissolved, cooled to 5-6 °c, and epichlorohydrin was slowly added. After the addition, the mixture was stirred at 25 ° C. For 45H. The reaction was extracted with ether, and the extract was dried with anhydrous potassium carbonate and filtered. The diethyl ether was recovered from the filtrate and distilled under reduced pressure to obtain an epoxy propyl phenyl ether fraction at a temperature of 1.46-123 °c (kPa).
category	toxic substances
toxicity grade	poisoning
Acute toxicity	oral-rat LD50: 3850 mg/kg; Oral-mouse LD50: 1400 mg/kg
stimulation data	Skin-rabbits 10 mg/24 h severe; eye-rabbit 111 mg mild
explosive hazard characteristics	can form peroxide; The latter can be exploded
flammability hazard characteristics	open flame flammability; Toxic vapor release when exposed to heat
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; Separate from food and oxidant
fire extinguishing agent	foam, dry powder, carbon dioxide, water mist
Occupational Standard	TWA 6 mg/m3; Tel 60 mg/m3
spontaneous combustion temperature	430°C
immediate life-and health-threatening concentration	100 ppm

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