Pharmaceutical Materials

Glabridin (CAS No.: 59870-68-7), a prenylated isoflavonoid extracted from Glycyrrhiza glabra , is recognized for its multifaceted pharmacological activities. As a potent antioxidant, it scavenges reactive oxygen species (ROS) and inhibits lipid peroxidation, making it valuable in dermatological and anti-aging formulations. Glabridin also exhibits anti-inflammatory properties by modulating PPARγ activation  and suppressing pro-inflammatory cytokines. Its melanogenesis-inhibiting effects are attributed to the downregulation of tyrosinase and TRP-1 enzymes, positioning it as a premium whitening agent in cosmetics. Additionally, glabridin demonstrates cardioprotective, neuroprotective, and anticancer potential through mechanisms involving apoptosis induction and cell cycle arrest. Its high stability and compatibility with organic solvents facilitate its incorporation into topical and systemic formulations.

Glabridin Usage： Used as pharmaceutical intermediate and cosmetics intermediate.

Packaging and Shipping：25kg/drum or as per buyer’s requirements.

Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

Item Results

melting point：154～155℃

purity ：99%

density：1.257±0.06 g/cm3

Name	Glabridin
Synonyms	Glabridin professional manufacturer Glabridin 59870-68-7 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol
CAS	59870-68-7
EINECS	611-908-7
InChI	InChI=1/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChIKey	PMPYOYXFIHXBJI-ZDUSSCGKSA-N

Molecular Formula	C20H20O4
Molar Mass	324.37
Density	1.257±0.06 g/cm3(Predicted)
Melting Point	154～155℃
Boling Point	518.6±50.0 °C(Predicted)
Specific Rotation(α)	(c, 2.07 in CHCl3)+8.2
Flash Point	267℃
Solubility	Insoluble in water, easily soluble in organic solvents, such as propylene glycol, etc.
Vapor Presure	2.26E-11mmHg at 25°C
Appearance	Pale yellow powder
Color	white to light brown
BRN	7141956
pKa	9.66±0.40(Predicted)
Storage Condition	room temp
Stability	Hygroscopic
Refractive Index	1.622
MDL	MFCD03427694
Physical and Chemical Properties	Dried rhizomes derived from Glycyrrhiza glabra

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