Glabridin CAS No.:59870-68-7
Pharmaceutical Materials 2025-03-03
Glabridin (CAS No.: 59870-68-7), a prenylated isoflavonoid extracted from Glycyrrhiza glabra , is recognized for its multifaceted pharmacological activities. As a potent antioxidant, it scavenges reactive oxygen species (ROS) and inhibits lipid peroxidation, making it valuable in dermatological and anti-aging formulations. Glabridin also exhibits anti-inflammatory properties by modulating PPARγ activation and suppressing pro-inflammatory cytokines. Its melanogenesis-inhibiting effects are attributed to the downregulation of tyrosinase and TRP-1 enzymes, positioning it as a premium whitening agent in cosmetics. Additionally, glabridin demonstrates cardioprotective, neuroprotective, and anticancer potential through mechanisms involving apoptosis induction and cell cycle arrest. Its high stability and compatibility with organic solvents facilitate its incorporation into topical and systemic formulations.
Glabridin Usage： Used as pharmaceutical intermediate and cosmetics intermediate.
Packaging and Shipping：25kg/drum or as per buyer’s requirements.
Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.
Item Results
melting point：154～155℃
purity ：99%
density：1.257±0.06 g/cm3
| Name | Glabridin |
| Synonyms | Glabridin professional manufacturer Glabridin 59870-68-7 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol |
| CAS | 59870-68-7 |
| EINECS | 611-908-7 |
| InChI | InChI=1/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1 |
| InChIKey | PMPYOYXFIHXBJI-ZDUSSCGKSA-N |
| Molecular Formula | C20H20O4 |
| Molar Mass | 324.37 |
| Density | 1.257±0.06 g/cm3(Predicted) |
| Melting Point | 154～155℃ |
| Boling Point | 518.6±50.0 °C(Predicted) |
| Specific Rotation(α) | (c, 2.07 in CHCl3)+8.2 |
| Flash Point | 267℃ |
| Solubility | Insoluble in water, easily soluble in organic solvents, such as propylene glycol, etc. |
| Vapor Presure | 2.26E-11mmHg at 25°C |
| Appearance | Pale yellow powder |
| Color | white to light brown |
| BRN | 7141956 |
| pKa | 9.66±0.40(Predicted) |
| Storage Condition | room temp |
| Stability | Hygroscopic |
| Refractive Index | 1.622 |
| MDL | MFCD03427694 |
| Physical and Chemical Properties | Dried rhizomes derived from Glycyrrhiza glabra |
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