Gimeracil
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017999
CAS NO.103766-25-2
Purity 99%
MDL NumberMFCD08458352
Molecular FormulaC5H4ClNO2
Molecular Weight145.5438
Melting point: 274~283°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C5H4ClNO2<br> Molecular weight: 145.54 g/mol |
| Physical Properties | Appearance: White to off-white solid<br> Melting point: 274°C |
| Mechanism of Action | Inhibits dihydropyrimidine dehydrogenase (DPD), an enzyme that degrades pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU). By inhibiting DPD, gimeracil prolongs the circulating concentrations of 5-FU, enhancing its antitumor activity. |
| Therapeutic Uses | Antitumor Agent: Used in combination with 5-FU or tegafur to treat advanced gastric cancer.<br> Radiosensitizer: Enhances the efficacy of radiotherapy by inhibiting homologous recombination in DNA double-strand break repair. |
| Pharmacokinetics | Absorption: Increases 5-FU plasma concentrations by inhibiting DPD.<br> Elimination: Approximately 65% to 72% of administered gimeracil is excreted unchanged in urine.<br> Half-Life: 3.1 to 4.1 hours. |
| Storage Conditions | Store in an inert atmosphere at -20°C. |
| Safety Information | Side Effects: Generally well-tolerated, but may cause gastrointestinal discomfort.<br> Contraindications: Avoid in patients with hypersensitivity to gimeracil |
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