Gemifloxacin mesylate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80071746
CAS NO.210353-53-0
Purity 98+%
MDL NumberMFCD08277637
Molecular Formula C18H20FN5O4.CH4O3O
Molecular Weight 485.491
| Category | Content |
|---|---|
| Generic Name | Gemifloxacin Mesylate Monohydrate |
| Brand Name | Factive |
| Chemical Formula | C18H20FN5O4·CH4O3S |
| CAS Number | 328853-27-4 |
| Mechanism of Action | Gemifloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication and transcription. |
| Indications | – Acute bacterial exacerbation of chronic bronchitis.<br>- Community-acquired pneumonia (mild to moderate severity) caused by susceptible strains. |
| Dosage Forms | Oral tablets (320 mg) |
| Administration | – Usual dose: 320 mg once daily for 5 to 7 days, depending on the infection.<br>- Can be taken with or without food. |
| Pharmacokinetics | – Rapidly absorbed from the gastrointestinal tract.<br>- Bioavailability: Approximately 71%.<br>- Excretion: 61% in feces, 36% in urine. |
| Common Side Effects | – Nausea, vomiting, diarrhea.<br>- Headache, dizziness.<br>- Insomnia. |
| Serious Side Effects | – Tendinitis and tendon rupture.<br>- QT interval prolongation.<br>- Hepatotoxicity.<br>- Severe allergic reactions. |
| Contraindications | Hypersensitivity to gemifloxacin or other fluoroquinolones. |
| Precautions | – Monitor for signs of tendinitis or tendon rupture.<br>- Use with caution in patients with renal impairment.<br>- Avoid in patients with a history of QT prolongation. |
| Storage | Store at 25°C (77°F); excursions permitted to 15°-30°C (59°-86°F). Protect from light. |
| Developer | GlaxoSmithKline (GSK) |
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