Fosfomycin Tromethamine CAS No. 78964-85-9
Pharmaceutical Materials 2025-03-20
Product Name
Fosfomycin Tromethamine
Multiple Names
Fosfomycin Tromethamine;
1.3-Dihydroxy-2-(Hydroxymethyl)Propan-2-AminiumHydrogen [(2R,3S)-3-Methyloxiran-2-Yl]Phosphonate;
[(2S,3R)-3-Methyloxiran-2-Yl]PhosphonicAcid – 2-Amino-2-(Hydroxymethyl)Propane-1.3-Diol (1:1);
Fosfomycin Trometamol
CAS No. 78964-85-9
EC No. 279-018-8
MF No. C7H18NO7P
MW No. 259.1941
Fosfomycin Tromethamine is used as antibiotics
Advantage of Fosfomycin Tromethamine CAS No. 78964-85-9
It is hygroscopic
Very soluble in water, slightly soluble in ethanol and in methanol, practically insoluble in aceton
It is widely used in Pharmaceutical field
| Property | Details |
|---|---|
| Chemical Name | Fosfomycin Tromethamine |
| CAS No. | 78964-85-9 |
| EINECS No. | 279-018-8 |
| Molecular Formula | C7H18NO7P |
| Molecular Weight | 259.19 g/mol |
| Physical State | White to off-white powder |
| Melting Point | N/A (decomposes before melting) |
| Boiling Point | 357°C at 760 mmHg |
| Solubility | Very soluble in water; slightly soluble in ethanol and methanol; practically insoluble in acetone. |
| Applications | Broad-spectrum antibiotic for treating urinary tract infections (UTIs), including those caused by multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Also used prophylactically in surgical procedures to prevent UTIs. |
| Mechanism of Action | Inhibits bacterial cell wall synthesis by irreversibly binding to UDP-N-acetylglucosamine enolpyruvyl transferase, blocking the first step of peptidoglycan biosynthesis. |
| Storage Conditions | Store at 2-8°C, protected from light and moisture. |
| Safety Precautions | Handle with care; avoid contact with skin and eyes. Consult safety data sheets (SDS) for detailed handling and disposal instructions. |
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