Pharmaceutical Materials

Product Name

Folinic Acid

Multiple Names

Folinic Acid;

5-Formyl-5.6.7.8-Tetrahydropteroyl-l-Glutamicacid; Leucoverin;

6-Formyl-5.6.7.8-Tetrahydrofolate;

5-Formyltetrahydrofolate;

6-Formyltetrahydrofolicacid;

N5-Formychemicalbookl-5.6.7.8-Tetrahydrofolate;

N5-Formyl-Tetrahydrofolate;

2-[4-[(2-Amino-5-Formyl-4-Oxo-1.6.7.8-Tetrahydropteridin-6-Yl)Methylamino]Benzoyl]Aminopentanedioicacid

CAS No. 58-05-9

EC No. 200-361-6

MF No. C20H23N7O7

MW No. 473.4393

Folic acid (calcium folinate) is a special form of reduced folic acid (folate). High dose folic acid intervention in children with CFD can improve their neurological and developmental abnormalities. Abnormal folate metabolism is related to the occurrence of autism in children. The genetic polymorphism of folate related pathway may lead to abnormal folate metabolism.

Advantage of Folinic Acid CAS No. 58-05-9

Can improve megaloblastic anemia

Reduce MTX-induced toxicity

It can stimulate the growth and maturation of white blood cells

Names and Identifiers

Name	5-formyltetrahydrofolic acid
Synonyms	leucoverin Folinic Acid 5-formyltetrahydrofolate N5-formyl-tetrahydrofolate 5-formyltetrahydrofolic acid 5-formyl-5,6,7,8-tetrahydrofolate N5-formyl-5,6,7,8-tetrahydrofolate 5-formyl-5,6,7,8-tetrahydropteroyl-l-glutamicacid N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid 2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
CAS	58-05-9
EINECS	200-361-6
InChI	InChI=1/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1

58-05-9 – Physico-chemical Properties

Molecular Formula	C20H23N7O7
Molar Mass	473.44
Density	1.4485 (rough estimate)
Melting Point	245°C (rough estimate)
Boling Point	573.92°C (rough estimate)
Specific Rotation(α)	D20 +14.26° (c = 3.42 as anhydr Ca salt)
Water Solubility	>1350g/L(25 ºC)
pKa	3.1, 4.8, 10.4(at 25℃)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.6800 (estimate)
In vitro study	MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .

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