fmoc-N-methyl-D-valine
Category：Active Pharmaceutical Ingredients
Introduction
fmoc-N-methyl-D-valine – Names and Identifiers
| Name | fmoc-N-methyl-D-valine |
| Synonyms | Fmoc-N-Me-D-Val-OH Fmoc-D-N-Me-Ala-OH Fmoc-D-N-Me-Val-OH fmoc-N-methyl-D-valine N-ALPHA-FMOC-N-ALPHA-METHYL-D-VALINE N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-D-valine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-valine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-D-VALINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-D-VALINE (R)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)-3-Methylbutanoic acid |
| CAS | 103478-58-6 |
| InChI | InChI=1/C21H23NO4/c1-13(2)19(20(23)24)22(3)21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,12H2,1-3H3,(H,23,24)/t19-/m1/s1 |
fmoc-N-methyl-D-valine – Physico-chemical Properties
| Molecular Formula | C21H23NO4 |
| Molar Mass | 353.41 |
| Density | 1.214±0.06 g/cm3(Predicted) |
| Boling Point | 527.6±29.0 °C(Predicted) |
| Flash Point | 272.9°C |
| Vapor Presure | 5.83E-12mmHg at 25°C |
| Appearance | Solid |
| pKa | 3.92±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.587 |
| MDL | MFCD00153396 |
fmoc-N-methyl-D-valine – Risk and Safety
| Safety Description | S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| Hazard Class | IRRITANT |
fmoc-N-methyl-D-valine – Introduction
Fmoc-N-Methyl-D-Valine is a chemical compound with the following properties:
1. Appearance: A white to light yellow crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF), dichloromethane, methanol, etc.
3. Stability: It is relatively stable at room temperature, but it will decompose under high temperature, strong acid or strong alkali conditions.
Fmoc-N-methyl-D-valine is commonly used in the field of biochemistry and medicinal chemistry, the main uses include:
1. Peptide synthesis: As a protecting group in peptide synthesis, the hydroxyl functional group of D-valine is protected so that the peptide chain can be selectively synthesized during the synthesis process.
2. drug research and development: as a synthetic intermediate of active peptides or proteins, it is often used in the research and development and synthesis of new drugs.
The preparation of Fmoc-N-methyl-D-valine can generally be carried out by the following steps:
1. Reaction of N-methyl-D-valine with Fmoc-chloroformate to give Fmoc-N-methyl-D-valine ester.
2. Fmoc-N-methyl-D-valine ester is then reacted with a base (such as triethylamine) or an amino acid coupling reagent to generate Fmoc-N-methyl-D-valine.
Regarding safety information, Fmoc-N-methyl-D-valine is irritating. It is recommended to wear appropriate protective equipment during operation and avoid contact with skin and eyes. At the same time, pay attention to avoid high temperature, fire source and strong acid and alkali conditions during use or storage.,Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
