Fluvastatin sodium
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80020570
CAS NO.93957-55-2
Purity 99%
MDL NumberMFCD00929076
Molecular FormulaC24H25FNNaO4
Molecular Weight433.4478
Melting point: 205~212°C
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₂₄H₂₆FNO₄<br>- Molecular Weight: 415.47 g/mol |
| Physical Properties | – Appearance: White to off-white crystalline powder<br>- Melting Point: 194-197°C<br>- Solubility: Slightly soluble in methanol |
| Mechanism of Action | – Inhibits HMG-CoA reductase, reducing cholesterol synthesis in the liver.<br>- Lowers LDL cholesterol and triglycerides, while increasing HDL cholesterol levels. |
| Clinical Uses | – Primary Hypercholesterolemia: Used to lower elevated LDL cholesterol levels.<br>- Mixed Dyslipidemia: Effective in reducing triglyceride levels.<br>- Coronary Heart Disease: Reduces cardiovascular events in high-risk patients. |
| Dosage | – Initial Dose: 20 mg or 40 mg daily.<br>- Maximum Dose: Up to 80 mg daily.<br>- Administration: Taken with or without food. |
| Adverse Effects | – Common: Headache, nausea, abdominal pain, diarrhea.<br>- Serious: Myopathy (muscle pain, weakness), rhabdomyolysis (muscle breakdown), liver damage (jaundice, dark urine, fatigue).<br>- Other: Increased blood sugar levels, allergic reactions. |
| Contraindications | – Hypersensitivity to fluvastatin.<br>- Active liver disease.<br>- Pregnancy and breastfeeding. |
| Storage Conditions | Store at room temperature (20-25°C), protect from light. |
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