Flurbiprofen CAS NO.5104-49-4
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017204
CAS NO.5104-49-4
Purity 98%
MDL NumberMFCD00079303
EINEC225-827-6
Molecular Formula C15H13FO2
Molecular Weight 244.2609
Melting point: 114~117 ℃
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C15H13FNO2<br>- Molecular Weight: 260.27 g/mol |
| Mechanism of Action | – Flurbiprofen is a non-selective COX inhibitor that blocks the activity of both COX-1 and COX-2 enzymes, reducing the production of prostaglandins responsible for pain and inflammation. |
| Indications | – Treatment of osteoarthritis and rheumatoid arthritis.<br>- Relief of postoperative pain and cancer pain. |
| Pharmacokinetics | – Rapidly absorbed after oral administration.<br>- Metabolized in the liver and excreted primarily via urine.<br>- Half-life: 4.7-5.8 hours. |
| Dosage Forms | – Oral tablets (100 mg).<br>- Injectable solutions for intravenous use. |
| Administration | – Oral: Typically taken 3 times daily.<br>- Intravenous: 50-100 mg per dose. |
| Adverse Effects | – Common: Stomach pain, nausea, indigestion.<br>- Serious: Gastrointestinal bleeding, ulcers, perforation.<br>- Other: Increased risk of heart attack or stroke. |
| Contraindications | – Hypersensitivity to flurbiprofen or other NSAIDs.<br>- Use before or after coronary artery bypass graft (CABG) surgery. |
| Special Considerations | – Use with caution in patients with liver or kidney disease.<br>- Monitor for signs of gastrointestinal bleeding or worsening of asthma symptoms.<br>- Avoid alcohol to reduce the risk of bleeding.<br>- Not recommended in pregnancy after 20 weeks.<br>- Caution in elderly patients due to increased risk of side effects. |
| Storage Conditions | Store at room temperature (68°F to 77°F; 20°C to 25°C), with excursions permitted between 59°F to 86°F (15°C to 30°C) |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
