Flurbiprofen CAS NO.5104-49-4
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017204
CAS NO.5104-49-4
Purity 98%
MDL NumberMFCD00079303
EINEC225-827-6
Molecular Formula C15H13FO2
Molecular Weight 244.2609
Melting point: 114~117 ℃
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C15H13FNO2<br>- Molecular Weight: 260.27 g/mol |
| Mechanism of Action | – Flurbiprofen is a non-selective COX inhibitor that blocks the activity of both COX-1 and COX-2 enzymes, reducing the production of prostaglandins responsible for pain and inflammation. |
| Indications | – Treatment of osteoarthritis and rheumatoid arthritis.<br>- Relief of postoperative pain and cancer pain. |
| Pharmacokinetics | – Rapidly absorbed after oral administration.<br>- Metabolized in the liver and excreted primarily via urine.<br>- Half-life: 4.7-5.8 hours. |
| Dosage Forms | – Oral tablets (100 mg).<br>- Injectable solutions for intravenous use. |
| Administration | – Oral: Typically taken 3 times daily.<br>- Intravenous: 50-100 mg per dose. |
| Adverse Effects | – Common: Stomach pain, nausea, indigestion.<br>- Serious: Gastrointestinal bleeding, ulcers, perforation.<br>- Other: Increased risk of heart attack or stroke. |
| Contraindications | – Hypersensitivity to flurbiprofen or other NSAIDs.<br>- Use before or after coronary artery bypass graft (CABG) surgery. |
| Special Considerations | – Use with caution in patients with liver or kidney disease.<br>- Monitor for signs of gastrointestinal bleeding or worsening of asthma symptoms.<br>- Avoid alcohol to reduce the risk of bleeding.<br>- Not recommended in pregnancy after 20 weeks.<br>- Caution in elderly patients due to increased risk of side effects. |
| Storage Conditions | Store at room temperature (68°F to 77°F; 20°C to 25°C), with excursions permitted between 59°F to 86°F (15°C to 30°C) |
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