Active Pharmaceutical Ingredients

Product Name: Fluorobenzene

Product use: Intermediate for pharmaceuticals and pesticides

Pharmaceutical intermediate and pesticide intermediate.

Pharmaceutical intermediate fluorobenzene: colorless liquid. Melting point -42 ℃. Boiling point is 85 ℃. Refractive index (nD20) 1.4650. Relative density (d420) 1.024. Insoluble in water, miscible with ethanol, ether, acetone, and benzene. Prepared from aniline via G. Schiemann reaction.

Obtained from aniline via Schiemann reaction. Aniline is salted with 31% hydrochloric acid, cooled to -8 ℃, and diazotized with sodium nitrite solution. Cool the diazonium solution to -10 ℃, add fluoroboric acid solution to generate fluoroboric acid diazonium salt with lower solubility, and filter. Dry fluoroboronic acid diazobenzene and conduct pyrolysis. At the same time, the generated fluorobenzene is distilled, and the distillate is washed with sodium hydroxide solution, then washed with water, dried, and distilled to obtain the finished product with a yield of about 53%. This method consumes a large amount of boric acid, produces a lot of waste gas, and has a high cost.

Storage method

Storage precautions: Store in a cool and ventilated warehouse. Stay away from sources of fire and heat. The storage temperature should not exceed 37 ℃. Keep the container sealed. It should be stored separately from oxidants and avoid mixing storage. Adopt explosion-proof lighting and ventilation facilities. Prohibit the use of mechanical equipment and tools that are prone to generating sparks. The storage area should be equipped with emergency response equipment for leaks and suitable containment materials.

Name	Fluorobenzene
Synonyms	FLUOROBENZENE Fluorobenzene fluoro benzene Fluorobenzenes Phenyl Fluoride Fluorine benzene monofluorobenzene FLUOROBENZENE FOR SYNTHESIS 5 ML FLUOROBENZENE FOR SYNTHESIS 250 ML
CAS	462-06-6
EINECS	207-321-7
InChI	InChI=1/C6H5F/c7-6-4-2-1-3-5-6/h1-5H
InChIKey	PYLWMHQQBFSUBP-UHFFFAOYSA-N

Molecular Formula	C6H5F
Molar Mass	96.1
Density	1.024g/mLat 25°C(lit.)
Melting Point	-42 °C
Boling Point	85°C(lit.)
Flash Point	9°F
Water Solubility	INSOLUBLE
Solubility	1.54g/l
Vapor Presure	81hPa at 20℃
Vapor Density	3.31 (vs air)
Appearance	Liquid
Specific Gravity	1.024
Color	Clear colorless
Merck	14,4170
BRN	1236623
Storage Condition	2-8°C
Stability	Stable. Incompatible with oxidizing agents. Highly flammable – note low flash point.
Explosive Limit	1.3-8.9%(V)
Refractive Index	n20/D 1.465(lit.)
Physical and Chemical Properties	Colorless liquid. Has a similar odor to benzene.
Use	It is mainly used for the preparation of antipsychotic drugs such as flumbutol, also used as pesticides, and used for the identification of plastics and resin polymers

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