Active Pharmaceutical Ingredients

Property

Details

Fluconazole

86386 – 73 – 4

\(C_{13}H_{12}F_{2}N_{6}O\)

306.27

Usually appears as a white to off – white crystalline powder.

Sparingly soluble in water. It is more soluble in organic solvents such as methanol and dimethyl sulfoxide (DMSO).

Stable under normal storage conditions. It should be stored in a cool, dry place away from light to maintain its integrity.

Triazole antifungal agent.

Fluconazole works by inhibiting the enzyme lanosterol 14 – α – demethylase in fungi. This enzyme is crucial for the synthesis of ergosterol, a major component of the fungal cell membrane. By blocking its production, Fluconazole disrupts the fungal cell membrane integrity, leading to the death of the fungus.

Widely used in the treatment of various fungal infections. It is effective against candidiasis (including oral, esophageal, and vaginal candidiasis), cryptococcal meningitis, and other systemic fungal infections. It can be administered orally or intravenously, depending on the severity and type of the infection. In immunocompromised patients, such as those with HIV/AIDS or undergoing chemotherapy, Fluconazole is often prescribed prophylactically to prevent fungal infections.

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, and headache. In rare cases, more serious side effects such as liver toxicity and allergic reactions can occur.