Fluconazole CAS: 86386-73-4
Active Pharmaceutical Ingredients 2025-03-03
White or almost white crystalline powder.Used as broad-spectrum
antifungal medicines.
Package: 25KG/drum, or as buyer request.
Storage: in a dry and ventilated warehouse; keep away from sunshine and moisture.
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Property
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Details
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Chemical Name
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Fluconazole
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CAS Number
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86386 – 73 – 4
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Molecular Formula
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\(C_{13}H_{12}F_{2}N_{6}O\)
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Molecular Weight
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306.27
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Appearance
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Usually appears as a white to off – white crystalline powder.
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Solubility
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Sparingly soluble in water. It is more soluble in organic solvents such as methanol and dimethyl sulfoxide (DMSO).
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Stability
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Stable under normal storage conditions. It should be stored in a cool, dry place away from light to maintain its integrity.
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Pharmacological Class
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Triazole antifungal agent.
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Mechanism of Action
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Fluconazole works by inhibiting the enzyme lanosterol 14 – α – demethylase in fungi. This enzyme is crucial for the synthesis of ergosterol, a major component of the fungal cell membrane. By blocking its production, Fluconazole disrupts the fungal cell membrane integrity, leading to the death of the fungus.
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Medical Uses
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Widely used in the treatment of various fungal infections. It is effective against candidiasis (including oral, esophageal, and vaginal candidiasis), cryptococcal meningitis, and other systemic fungal infections. It can be administered orally or intravenously, depending on the severity and type of the infection. In immunocompromised patients, such as those with HIV/AIDS or undergoing chemotherapy, Fluconazole is often prescribed prophylactically to prevent fungal infections.
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Side Effects
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Common side effects may include nausea, vomiting, diarrhea, abdominal pain, and headache. In rare cases, more serious side effects such as liver toxicity and allergic reactions can occur.
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