Active Pharmaceutical Ingredients

Molecular Formula: C13H12F2N6O

Molecular Weight: 306.271

CAS No.: 86386-73-4

It is a fluorotriazole antifungal drug. Its antibacterial spectrum is similar to that of ketoconazole, and its antibacterial activity is stronger than that of ketoconazole. Fluconazole has strong antibacterial activity against Candida albicans, Large and Small Spores, Cryptococcus neoformans, Epidermophytes and Histoplasma capsulatus.

Description

It is a white or almost white, hygroscopic, crystalline powder, it’s slightly soluble in water, freely soluble in methanol, soluble in acetone.

Application

It is a fluorotriazole antifungal drug. Its antibacterial spectrum is similar to that of ketoconazole, and its antibacterial activity is stronger than that of ketoconazole. Its mechanism of action is to inhibit ergosterol synthase, an essential component of fungal cell membranes, hinder the synthesis of ergosterol, destroy the integrity of the fungal cell wall, and inhibit its growth and reproduction. Fluconazole has strong antibacterial activity against Candida albicans, Large and Small Spores, Cryptococcus neoformans, Epidermophytes and Histoplasma capsulatus.

Packing

25Kg per drum

Storage：

Preserve in tight containers in a dry place.

Shelf Life :

24 months from date of production when stored in good condition.

Minimum Order

One package

Item	Content
Chemical Information	– Molecular Formula: C₁₃H₁₂F₂N₆O<br>- Molecular Weight: 306.27
Appearance	White or almost white, hygroscopic crystalline powder; soluble in methanol, slightly soluble in water
Indications	– Candidiasis: Including oropharyngeal, esophageal, and disseminated candidiasis<br>- Cryptococcosis: Including cryptococcal meningitis<br>- Coccidioidomycosis
Mechanism of Action	Inhibits the synthesis of ergosterol in fungal cell membranes, disrupting the integrity of the fungal cell wall and inhibiting fungal growth and reproduction
Specifications	– Purity: 99.0%–101.0% on the dried basis<br>- Impurities: Individual impurity ≤0.5%, total impurities ≤1.0%
Storage Conditions	Store in a tightly closed container in a dry place. Shelf life is 24 months from the date of manufacture
Packaging	25Kg/drum
Pharmacopoeia Standard	Complies with British Pharmacopoeia BP2013
Adverse Reactions	– Common: Nausea, headache, rash<br>- Serious: Hepatic dysfunction, allergic reactions
Dosage and Administration	– Disseminated Candidiasis: Initial dose 0.4 g, followed by 0.2 g once daily<br>- Esophageal Candidiasis: Initial dose 0.2 g, followed by 0.1 g once daily

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