Active Pharmaceutical Ingredients

Molecular Formula: C12H14Cl2FNO4S

Molecular Weight: 358.21

CAS No.: 73231-34-2

Application:Florfenicol can strongly interfere with bacterial protein synthesis, with rapid absorption, wide distribution in the body, long half-life, no aplastic anemia side effects, no drug resistance, no residue, no cross resistance. Florfenicol can be used for the treatment of systemic infection in livestock, poultry and aquatic animals produced by chemicalbook. It has a significant effect on respiratory system infection and intestinal infection. Poultry: mixed infection caused by various sensitive bacteria such as colibacillosis, salmonellosis, infectious rhinitis, chronic respiratory diseases and duck plague.

Packing:25kg/bag or as customer’s requirements.

Storage:Store in airtight, tamper- proof container.

Florfenicol: A Veterinary Antibiotic

Florfenicol is an important antibiotic in veterinary medicine, used for treating and preventing a variety of infections in animals.

1. General Information

Aspect	Details
Classification	Amphenicol – type antibiotic
Source	Synthetically produced
Formulation	Available as powders, premixes for feed, soluble powders for drinking water, and injectable solutions
Solubility	Slightly soluble in water. Special formulations are designed to enhance its solubility and bioavailability for different routes of administration

2. Mechanism of Action

Action	Explanation
Inhibition of Protein Synthesis	Florfenicol binds to the 50S ribosomal subunit of bacteria. It blocks the peptidyl transferase activity, which is essential for the formation of peptide bonds during protein synthesis. This binding prevents the addition of new amino acids to the growing polypeptide chain, thus inhibiting bacterial protein synthesis.
Selective Activity	It has a broad – spectrum antibacterial effect, targeting both Gram – positive and Gram – negative bacteria. The unique binding site on the ribosome of these bacteria allows florfenicol to exert its inhibitory action.

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating respiratory tract infections in poultry, swine, and cattle. In poultry, it is effective against Escherichia coli, Pasteurella multocida, and Mycoplasma gallisepticum. In swine, it combats infections caused by Actinobacillus pleuropneumoniae, Haemophilus parasuis, and Salmonella spp. – Used to control enteric infections in livestock, such as diarrhea caused by pathogenic Escherichia coli in piglets. – Sometimes used in aquaculture to treat bacterial infections in fish, like Aeromonas hydrophila.
Considerations	– Overuse can lead to the development of antibiotic – resistant bacteria. Adhering to proper dosage and treatment duration as prescribed by veterinarians is crucial. – Prolonged or high – dose use may cause bone marrow suppression in some animals, although this is relatively rare. Monitoring of blood parameters may be necessary in long – term treatments. – Caution is required when using it in combination with other drugs, as there may be potential drug – drug interactions. For example, it may interact with some drugs that also affect protein synthesis, leading to enhanced or altered effects.

Florfenicol plays a significant role in maintaining the health and productivity of livestock, poultry, and in aquaculture.

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