Fenoldopam CAS NO.67227-56-9
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017651
CAS NO.67227-56-9
Purity 96%
MDL NumberMFCD00865806
Molecular Formula C16H16ClNO3
Molecular Weight 305.7561
Melting point: 195 – 211°C
| Aspect | Details |
|---|---|
| Mechanism of Action | Fenoldopam is a selective dopamine D1 receptor agonist. It primarily acts on renal and mesenteric vascular beds, reducing peripheral vascular resistance and increasing renal blood flow. It also promotes natriuresis and diuresis, which contribute to its antihypertensive effects. |
| Indications | – Used for the rapid reduction of blood pressure in hypertensive emergencies.<br>- Beneficial in hypertensive patients with chronic kidney disease due to its renal protective effects. |
| Pharmacokinetics | – Onset of action: 5 minutes in children, 10 minutes in adults.<br>- Half-life: 3 to 5 minutes in children, 5 minutes in adults.<br>- Metabolized in the liver and excreted primarily in urine. |
| Administration | – Administered via continuous intravenous (IV) infusion using an infusion pump.<br>- Adult dosing: Initial dose of 0.01 to 0.3 mcg/kg/minute, titrated up to a maximum of 1.6 mcg/kg/minute.<br>- Pediatric dosing: Initial dose of 0.2 mcg/kg/minute, titrated up to a maximum of 0.8 mcg/kg/minute. |
| Adverse Effects | – Common: Flushing, headache, nausea, hypotension, tachycardia.<br>- Uncommon: Chest pain, bradycardia, myocardial infarction, anxiety, dizziness, insomnia. |
| Special Considerations | – Monitor blood pressure closely during administration.<br>- Use with caution in patients with severe cardiovascular disease.<br>- No dose adjustment required for renal or hepatic impairment. |
| Pregnancy and Lactation | Safety in pregnancy has not been established; no fetal harm was observed in animal studies. |
| Storage Conditions | Store at room temperature, protected from light and moisture |
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