Etofibrate
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80071743
CAS NO.31637-97-5
Purity 98%
MDL NumberMFCD00865727
Molecular Formula C18H18ClNO5
Molecular Weight 363.79
| Category | Content |
|---|---|
| Generic Name | Etofibrate |
| Chemical Formula | C18H18ClNO5 |
| CAS Number | 31637-97-5 |
| Mechanism of Action | Etofibrate is a combination of clofibrate and niacin. It inhibits the synthesis of cholesterol and triglycerides, increases fecal excretion of sterols, and reduces plasma lipid levels. |
| Indications | – Treatment of hyperlipidemia (severe primary and secondary hyperlipidemia).<br>- Prevention of atherosclerosis, cerebral vascular disorders, and peripheral vascular diseases.<br>- Used for the prevention of stroke, myocardial infarction, hypertension, and obesity. |
| Dosage Forms | Tablets, capsules. |
| Administration | – Taken orally, usually with food to reduce gastrointestinal side effects.<br>- Dose varies based on the severity of the condition. |
| Common Side Effects | – Nausea, vomiting, diarrhea.<br>- Headache, dizziness.<br>- Muscle pain, tenderness, or weakness. |
| Serious Side Effects | – Liver damage (e.g., jaundice, dark urine, pale stools).<br>- Muscle breakdown (rhabdomyolysis), leading to kidney damage.<br>- Blood disorders (e.g., agranulocytosis, thrombocytopenia).<br>- Gallstones. |
| Precautions | – Regular monitoring of liver function and blood tests.<br>- Use with caution in patients with liver or kidney disease.<br>- Avoid in patients with a history of severe allergic reactions to similar medications. |
| Storage | Store at room temperature, protect from moisture. |
| Developer | Merz Pharma GmbH & Co. KGaA (originally developed in Germany) |
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