Ethyl fluoroacetate
Pharmaceutical Materials 2025-03-02
CAS Number: 459-72-3
Molecular Formula: C4H7FO2
Molecular Weight: 106.096 g/mol
Appearance: Colorless liquid with an ethyl acetate-like odor
Boiling Point: 118-119.3 °C
Density: 1.0±0.1 g/cm3
Usage: Used as a pharmaceutical intermediate in the synthesis of 5-fluorouracil and fluorocytosine.
| Category | Information |
|---|---|
| Basic Information | |
| Chemical Name | Ethyl fluoroacetate |
| Other Names | Fluoroacetic acid ethyl ester; Ethyl fluoroethanoate |
| CAS Number | 459-72-3 |
| Chemical Formula | C4H7FO2 |
| Molar Mass | 106.096 g/mol |
| EINECS Number | 207-297-8 |
| Physical Properties | |
| Appearance | Colorless liquid with an odor similar to ethyl acetate |
| Density | 1.098 g/cm³ at 25°C |
| Boiling Point | 119.3°C at 760 mmHg |
| Flash Point | 30°C (or 31°C, 86°F according to some sources) |
| Refractive Index | 1.375 at 20°C |
| Solubility | Decomposes in water |
| Chemical Properties | |
| Molecular Structure | Contains an ester group (COO) and a fluoro group (F) |
| Reactivity | May react with oxidizing agents, acids, bases, and reducing agents |
| Stability | Stable under normal conditions, but may decompose if exposed to heat or flame |
| Applications | |
| Industrial Use | Used as an intermediate in organic synthesis and pharmaceutical production |
| Pharmaceutical Use | Used in the synthesis of 5-fluorouracil and fluorocytosine, which are used to treat cancer |
| Safety Information | |
| Hazard Classification | Flammable liquid; toxic by ingestion |
| Health Hazards | Vapors and liquid may cause irritation to eyes and respiratory system |
| Environmental Hazards | May cause pollution to water bodies |
| Safety Precautions | Store in a cool, well-ventilated place away from heat, sparks, and open flames; avoid contact with skin, eyes, and clothing; wear appropriate protective clothing, gloves, and eye protection; in case of contact, rinse skin and eyes thoroughly with water and seek medical attention if necessary |
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