Agrochemicals

Ethyl Butylacetylaminopropionate (CAS No. 52304-36-6) 

1. Basic Information

• Chemical Name: Ethyl 3-(butylacetamido)propanoate
• INCI Name: Ethyl butylacetylaminopropionate
• Trade Names: IR3535®, Merck Insect Repellent
• CAS Number: 52304-36-6
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.29 g/mol
• Appearance: Colorless to pale yellow liquid
• Odor: Mild, characteristic ester-like odor

2. Physical and Chemical Properties

• Boiling Point: ~300°C (572°F) (decomposes)
• Density: 0.998–1.008 g/cm³ at 20°C
• Refractive Index: 1.442–1.447 at 20°C
• Solubility:
  • Water: Slightly soluble (~1.2 g/L at 25°C)
  • Organic solvents: Miscible with ethanol, propylene glycol, oils
• Flash Point: >100°C (>212°F) (non-flammable)
• Vapor Pressure: <0.01 hPa at 20°C

3. Chemical Structure

       O  
      ║  
CH₃-CH₂-C-NH-CH₂-CH₂-COO-CH₂-CH₃  
      |  
     CH₂  
      |  
     CH₂  
      |  
     CH₃

4. Hazards (GHS Classification)

• Acute Toxicity: Not classified (LD50 >2,000 mg/kg oral, rat)
• Skin Irritation: Non-irritating (OECD 404 tested)
• Eye Irritation: Mild irritant (Category 2B)
• Environmental Impact: Readily biodegradable (OECD 301)

5. Storage and Handling

• Storage:
  • Keep in tightly closed containers at room temperature
  • Avoid prolonged exposure to light/heat
• Handling:
  • Standard laboratory precautions (gloves, goggles)
  • No special ventilation required

6. Applications

• Insect Repellent: Effective against mosquitoes, ticks, and flies (EPA-registered)
• Cosmetics: Used in lotions, sprays (up to 20% concentration)
• Pharmaceuticals: Topical formulations

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