Ethyl 2-bromo-2-methylpropionate
We are a manufacturer based in China. We specialize in providing high-quality Ethyl 2-bromo-2-methylpropionate for industrial clients across various sectors. Whether you need chemicals consultation or technical support, our team is here to help.
Category：Chemical Additives Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Ethyl 2-Bromo-2-methylpropionate
Chemical Formula: C₆H₁₁BrO₂
Structure: Halogenated ester with:
- An ethyl ester group (-COOCH₂CH₃).
- A 2-bromo-2-methylpropionate backbone:
- Bromine atom (-Br) and methyl group (-CH₃) bonded to the same carbon adjacent to the carbonyl group.
Physical Properties
- Appearance: Clear, colorless to pale yellow liquid.
- Odor: Mild ester-like odor.
- Reactivity:
- Moisture-sensitive: Reacts with water/humidity.
- High reactivity in alkylation and nucleophilic substitution reactions.
Applications
- Organic Synthesis:
- Reagent for introducing 2-bromo-2-methylpropionyl groups into molecules.
- Synthesis of pharmaceuticals (e.g., bioactive molecules) and agrochemicals.
- Biomolecule Modification:
- Functionalizes peptides and proteins via alkylation.
- Polymer & Specialty Chemicals:
- Intermediate for polymers (e.g., acrylic resins) and specialty chemicals.
Safety Considerations ⚠️
- Health Hazards:
- Causes severe irritation to skin, eyes, and respiratory system.
- Handling:
- Use PPE (gloves, goggles, respirator) and work in a fume hood.
- Storage:
- Store in a cool, dry, airtight container away from moisture and incompatible substances (e.g., strong bases, oxidizers).
Summary:
Ethyl 2-bromo-2-methylpropionate’s reactive halogenated ester structure drives its use in drug discovery, agrochemicals, and polymer chemistry. Strict safety protocols are essential due to its irritant properties and moisture sensitivity.
Ethyl 2-Bromo-2-methylpropionate Technical Overview
1. Fundamental Chemical Properties
| Property | Specification |
|---|---|
| Chemical Name | Ethyl 2-bromo-2-methylpropionate |
| CAS Number | 600-00-0 |
| Molecular Formula | C₆H₁₁BrO₂ |
| Molecular Weight | 195.06 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 155-157°C |
| Density (25°C) | 1.328 g/cm³ |
| Refractive Index | 1.438-1.442 |
| Solubility | Soluble in most organic solvents |
| Flash Point | 52°C (closed cup) |
2. Key Applications and Reactivity
| Application Area | Primary Use |
|---|---|
| Pharmaceutical Synthesis | Alkylating agent for active pharmaceutical ingredients |
| Polymer Chemistry | Initiator for atom transfer radical polymerization (ATRP) |
| Organic Synthesis | Building block for ester derivatives |
| Agrochemicals | Intermediate for crop protection agents |
| Reactivity Characteristic | Description |
|---|---|
| Electrophilic Reactivity | High at brominated carbon |
| Hydrolytic Stability | Stable under neutral conditions |
| Thermal Decomposition | >200°C |
| Storage Stability | 12+ months at 2-8°C under inert gas |
3. Safety and Handling Considerations
| Safety Aspect | Requirement |
|---|---|
| Storage Conditions | Refrigerated, under nitrogen atmosphere |
| Personal Protection | Chemical-resistant gloves, face shield |
| Ventilation | Required in handling areas |
| Fire Fighting Measures | Alcohol-resistant foam, dry chemical |
| First Aid Measures | Flush eyes/skin with water if contacted |
This brominated ester compound is particularly valuable in controlled polymerization processes and specialty chemical synthesis. Its α-bromoester structure makes it a versatile intermediate for carbon-carbon bond formation reactions.
If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.
Inquiry
Factory & Shipment
